ID   G3HJ73_CRIGR            Unreviewed;      1210 AA.
AC   G3HJ73;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   SubName: Full=Eosinophil peroxidase {ECO:0000313|EMBL:EGV96614.1};
GN   ORFNames=I79_010707 {ECO:0000313|EMBL:EGV96614.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV96614.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC         Evidence={ECO:0000256|ARBA:ARBA00001970};
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DR   EMBL; JH000425; EGV96614.1; -; Genomic_DNA.
DR   AlphaFoldDB; G3HJ73; -.
DR   STRING; 10029.G3HJ73; -.
DR   PaxDb; 10029-XP_007638206-1; -.
DR   eggNOG; KOG2408; Eukaryota.
DR   InParanoid; G3HJ73; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd09824; myeloperoxidase_like; 1.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 3.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   PANTHER; PTHR11475:SF108; MYELOPEROXIDASE; 1.
DR   PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR   Pfam; PF03098; An_peroxidase; 2.
DR   PRINTS; PR00457; ANPEROXIDASE.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 3.
DR   PROSITE; PS50292; PEROXIDASE_3; 2.
PE   4: Predicted;
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Peroxidase {ECO:0000313|EMBL:EGV96614.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1210
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003444595"
FT   BINDING         927
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   1210 AA;  136203 MW;  B3692C735C15EA18 CRC64;
     MKLLLALVGV LATFILTQPS EGTAPASQVE DSVLRDCIAE AKLMVDAAYN WTQKSIKQRL
     SSGSARPMDL LAYFKQPVAA TKRVVQAADY MHVALGLLEE KLQSQGSRSF NVTDVLTESQ
     LRLLSQASGC ALQDKVERCS NKYRTITGRC NNKKRPWLGA SNQALARWLP AEYEDRRSLP
     FGWTSGKRRN GFLLPLVRAV SNQIVRFPSN KLASDQGRSL MFMQWGQFID HDLDFSPESP
     ARVAFTVGVD CEKTCAQLPP CFPIKIPPND PRIKNQRDCI PFFRSAPACP QNKNKVRNQI
     NALTSFVDAS MVYGSEVSLA LRLRNRTNFW GLLATNQRFQ DNGRSLLPFD NLHEDPCLLT
     NRSARIPCFL AGDTRASETP KLTSLHTLFV REHNRLATEL RRLNPGWSGD KLYNEARKIV
     GAMVQIITYR DFLPLVLGKA RIRRTLGPYR GYCSNVDPRV ANVFTLAFRF GHTMLQPFMF
     RLDSQYRASQ INSHVPLSSV FFASWRVVHE GGIDPILRGL MATPAKLNRQ DSMMVDELRD
     KLFQQVRRIG LDLAALNMQR SRDHGLPDVL TPAQLNLLSK SSGCAYQDVR VTCPEQDKYR
     TITGHCNNKG SPMLGATNSS FARWLPAEYE DGFSLPFGRT PRVKRSGFTV PLAGAVSNDN
     VRFPNDQLTR DQEQRSLLAV QFGQFLDHDI FLTREPAAWF FTGLNCETSC LQQPPCFPLK
     IPPNDPRIKS QEDCIPFFHS CPACTWSNIT IGNQVNEVTS FVDASAVYGS EDPLARRLRN
     LTNQLGLLAV NTRFRDNGRA LMPFDNLHDD PCLLTNRSAR IPCFLAGDMR SSEMPELTSM
     HTLFLREHNR LATQLKSLNP RWSGERLYQE ARKIVGAMVQ IITYRDYLPL VLGPAAMRTY
     LPRYRGYSDS VDPRIAKVFT KTFRYGHTLI QPFMFRLDNQ YRPTGHNPQV PLSKAHFSSW
     RIVLGGGIDP IIRGLMATPA KLNHQNRIVV DEIRERLFEQ VMRIGQDHLA LNMQRSRDHG
     LPGYNAWRRF CGLPQPNTVG ELGTVLKNMG LAQKLMAQYG TPNNIDIWMG GVSEPLEPNG
     QVGPLLACLI GTQFRKLRDG DRAESSVALS HSGGSSSQVM SSQPRVLCLG TSSDTVSMML
     PRRFWWEKPG VFSAQQRRAL ASISLPRIIC DNTGITTVSK NNIFMSNSYP RDFVNCTSIP
     KLNLASWREA
//