ID G3HJ99_CRIGR Unreviewed; 1218 AA.
AC G3HJ99;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Signal-induced proliferation-associated 1-like protein 3 {ECO:0000313|EMBL:EGV93009.1};
GN ORFNames=I79_010741 {ECO:0000313|EMBL:EGV93009.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV93009.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
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DR EMBL; JH000426; EGV93009.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HJ99; -.
DR STRING; 10029.G3HJ99; -.
DR InParanoid; G3HJ99; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF15; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 3; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 452..669
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 796..860
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1089
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1218 AA; 133655 MW; 6A7AECEF389B7807 CRC64;
MRNFQNGQLP SSTPASSGSR AYHRLSRRRS KDVEIQDGWP PPPGRAFLPL RHRSSSEITL
SECDVEEPGE ARGARHPGVL PLFREYGSTS SIDVQGVPEQ SFFDILNEFR SEQPEARGSQ
NLSELLRVDP GTLLSGSSCG AKGDPRNGQP AKDSLQTVQP LKEKEKARKK PAWGLGSGDT
VDSSIFRKLR SSKPEGEVGR SLGETEEGRS PPEASRPWVC QKSFAHFDVQ SMLFDLNEAA
ANRVSVAQRR NTTTGASAAS AASAMATLTA SRAHSLGTLD PAFTSTEDLN CKENLEQDLG
DDNSNDLLLS CPHFRNEIGG ERERNVSFSQ ASLGIEHVDL GARYYQDYFV GKEHANYFGV
DEKLGPVAVS IKREKLEDHK DHGPQYQYRI IFRTRELITL RGSILEDATP TATKHGTGRG
LPLKDALEYV IPELNIHCLR LALNTPKVTE QLLKLDEQGL CRKHKVGILY CKAGQSSEEE
MYNNEEAGPA FEEFLDLLGE KVCLKGFTKY AAQLDVKTDS TGTHSLYTTY QDYEVMFHVS
TLLPYTPNNR QQLLRKRHIG NDIVTIIFQE PGALPFTPKN IRSHFQHVFI IVRVHNPCTE
NVCYSMAVTR SKDAPPFGPP IPNGTTFRKS DVFRDFLLAK VINAENAAHK SDKFHTMATR
TRQEYLKDLA ESCVSNTPID SSGKFTLISL TSKKKEKTKA RAGAEQHSAG AIAWRIDCIL
GISNEFVVLL DLRTKEVVFN CYCGDVIGWT PDSSTLKIFY GRGDHIFLQA AEGSVEDIRD
IVQRLKVMTN GWETVDMTLR RNGLGQLGFH VKYDGTVAEV EDYGFAWQAG LRQGSRLVEI
CKVAVVTLSH DQMIDLLRTS VTVKVVIIPP FEDGTPRRGW PETYDMNTSE PKTESETTTP
GGRPPYRSNA PWQWSGPASH NSLPATKWTT PATPGHAQSL SRLPKQTPMV PFRESQPLHS
KQYTAAPHPL LSFDPHFIHD GMSSGDSPWS AQNQSTSEGT WAPGCPGLPL ELQLRAGSSC
SHGLSKPLWH VPAQSRLSAM AGSSGIKHPS RQDAAGKDSP NRHSKGEPQY SSHSSSNTLS
SNASSSHSDD RWFDPLDPLE PEQDPFSKGG SSDSGIDTTL YTSSPSCMSL AKAPRPTKPH
KPPGSIGLCG GGREVAGRPH PADRRREVSP APVVAGQNKG YRPKLYSSGS STPPGLVGGS
TKATQVRCHT SSWSSGGP
//
