ID G3HK28_CRIGR Unreviewed; 460 AA.
AC G3HK28;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Protein unc-93 homolog A {ECO:0000256|ARBA:ARBA00040854};
GN Name=Unc93a {ECO:0000313|Ensembl:ENSCGRP00001028082.1,
GN ECO:0000313|RefSeq:XP_027256769.1};
GN ORFNames=I79_011046 {ECO:0000313|EMBL:EGW13516.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13516.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW13516.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001028082.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027256769.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027256769.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027256769.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the unc-93 family.
CC {ECO:0000256|ARBA:ARBA00009172}.
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DR EMBL; JH000449; EGW13516.1; -; Genomic_DNA.
DR RefSeq; XP_003504101.1; XM_003504053.1.
DR RefSeq; XP_007607741.1; XM_007609551.1.
DR RefSeq; XP_027256769.1; XM_027400968.2.
DR STRING; 10029.G3HK28; -.
DR PaxDb; 10029-XP_007607741-1; -.
DR Ensembl; ENSCGRT00001032330.1; ENSCGRP00001028082.1; ENSCGRG00001024904.1.
DR GeneID; 100772557; -.
DR KEGG; cge:100772557; -.
DR CTD; 54346; -.
DR eggNOG; KOG3097; Eukaryota.
DR GeneTree; ENSGT00530000063359; -.
DR OMA; SFIAYMP; -.
DR OrthoDB; 1275866at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR CDD; cd17406; MFS_unc93A_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR010291; Ion_channel_UNC-93.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR19444:SF13; PROTEIN UNC-93 HOMOLOG A; 1.
DR PANTHER; PTHR19444; UNC-93 RELATED; 1.
DR Pfam; PF05978; UNC-93; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 460 AA; 51082 MW; 8FCF4D4160E3F4B3 CRC64;
MEKNLKNVLV VSCGFFLLFT AYGGLQNLQS SLYSENGMGV VTLSTIYCTM MVSSLLLPPI
LIKRFGCKWT MVGSMCCYTI FSLANFYATW YTLIPTSVLL GLGAGPLWSA QCTYITIIGN
LQAQKKGKLP KDVVTQYFGI FFLIFQSSGV WGNLISSLVF SHTTTKATIP EDQLLFCGAK
DCGSLGTEAS NSTHHPSQQL IYTLLGIFNG SSFLAILLLS VCLESVENRL INEGEARPVS
PSIWSIILST FTLFKDKRLC LLILLPLYSG LNQGFLYGEY TKSYTTCALG IHFVGYVMIC
FSAFTSMCSM LYGKISKYIG RAVLYGMGAT IHLSCFTTLL LWRPAPAQLP IFFIIPALWG
MSDAVWQTQN NALYGLLFEW KKEAAFANYR LGEAMGFLVA FGYSSFLCVR TKLYILFGML
SLTVTAYGTV EYMEFRAARK VPAVKEEKSQ PEKEEVKAEM
//
