ID G3HKF2_CRIGR Unreviewed; 319 AA.
AC G3HKF2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=C1q and tumor necrosis factor related protein 3 {ECO:0000313|Ensembl:ENSCGRP00001024385.1};
DE SubName: Full=Complement C1q tumor necrosis factor-related protein 3 {ECO:0000313|EMBL:EGV92305.1, ECO:0000313|RefSeq:XP_027257070.2};
GN Name=C1qtnf3 {ECO:0000313|RefSeq:XP_027257070.2};
GN ORFNames=I79_011172 {ECO:0000313|EMBL:EGV92305.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV92305.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|EMBL:EGV92305.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCGRP00001024385.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_027257070.2}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027257070.2};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027257070.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH000458; EGV92305.1; -; Genomic_DNA.
DR RefSeq; XP_027257070.2; XM_027401269.2.
DR PaxDb; 10029-XP_007624211-1; -.
DR Ensembl; ENSCGRT00001028631.1; ENSCGRP00001024385.1; ENSCGRG00001022324.1.
DR KEGG; cge:100758853; -.
DR eggNOG; ENOG502QSK2; Eukaryota.
DR GeneTree; ENSGT00940000161378; -.
DR OMA; HANKWTN; -.
DR OrthoDB; 4208355at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
DR GO; GO:0035356; P:intracellular triglyceride homeostasis; IEA:Ensembl.
DR GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR GO; GO:1901223; P:negative regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0070165; P:positive regulation of adiponectin secretion; IEA:Ensembl.
DR GO; GO:0001819; P:positive regulation of cytokine production; IEA:Ensembl.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427:SF49; C1Q DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..319
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157665"
FT DOMAIN 186..319
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 42..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 319 AA; 35040 MW; D85881FF11EEC01C CRC64;
MLRRQIVWWH LLALLFLPFC LCQDEYMEVS GRANKAVARI VQSHQQTGRS GSRRERVRER
SHAKTGTVDN NTSTDLKPLR PDELPHPEVE DLAQINPFWG QSPQTGGLPP DCSKCCHGDY
GFRGYQGPPG PPGPPGIPGN HGNNGNNGAT GHEGAKGEKG DKGDLGPRGE RGQHGPKGEK
GYPGVPPELQ IAFMASLATH FSNQNSGIIF SSVETNIGNF FDVMTGRFGA PVSGVYFFTF
SMMKHEDVEE VYVYLMHNGN TVFSMYSYET KGKSDTSSNH AVLKLAKGDE VWLRMGNGAL
HGDHQRFSTF AGFLLFETK
//
