ID G3HKQ3_CRIGR Unreviewed; 186 AA.
AC G3HKQ3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Nucleoside diphosphate kinase {ECO:0000256|RuleBase:RU004013};
DE EC=2.7.4.6 {ECO:0000256|RuleBase:RU004013};
GN Name=Nme6 {ECO:0000313|Ensembl:ENSCGRP00001001625.1,
GN ECO:0000313|RefSeq:XP_027270439.1, ECO:0000313|RefSeq:XP_027270440.1,
GN ECO:0000313|RefSeq:XP_027270441.1, ECO:0000313|RefSeq:XP_027270442.1,
GN ECO:0000313|RefSeq:XP_027270443.1};
GN ORFNames=I79_011282 {ECO:0000313|EMBL:EGV92142.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV92142.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV92142.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001001625.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027270439.1, ECO:0000313|RefSeq:XP_027270440.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027270439.1,
RC ECO:0000313|RefSeq:XP_027270440.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027270439.1,
RC ECO:0000313|RefSeq:XP_027270440.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-
CC deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316,
CC ChEBI:CHEBI:456216; EC=2.7.4.6;
CC Evidence={ECO:0000256|RuleBase:RU004013};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the NDK family. {ECO:0000256|ARBA:ARBA00008142,
CC ECO:0000256|RuleBase:RU004011}.
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DR EMBL; JH000468; EGV92142.1; -; Genomic_DNA.
DR RefSeq; XP_003504293.1; XM_003504245.3.
DR RefSeq; XP_007632946.1; XM_007634756.2.
DR RefSeq; XP_007642976.1; XM_007644786.2.
DR RefSeq; XP_007642977.1; XM_007644787.2.
DR RefSeq; XP_007642978.1; XM_007644788.2.
DR RefSeq; XP_007642979.1; XM_007644789.1.
DR RefSeq; XP_016827955.1; XM_016972466.1.
DR RefSeq; XP_016827956.1; XM_016972467.1.
DR RefSeq; XP_016827957.1; XM_016972468.1.
DR RefSeq; XP_016827958.1; XM_016972469.1.
DR RefSeq; XP_016827959.1; XM_016972470.1.
DR RefSeq; XP_016832055.1; XM_016976566.1.
DR RefSeq; XP_027270439.1; XM_027414638.2.
DR RefSeq; XP_027270440.1; XM_027414639.1.
DR RefSeq; XP_027270441.1; XM_027414640.2.
DR RefSeq; XP_027270442.1; XM_027414641.2.
DR RefSeq; XP_027270443.1; XM_027414642.2.
DR STRING; 10029.G3HKQ3; -.
DR PaxDb; 10029-XP_007632946-1; -.
DR Ensembl; ENSCGRT00001001840.1; ENSCGRP00001001625.1; ENSCGRG00001001441.1.
DR GeneID; 100763307; -.
DR KEGG; cge:100763307; -.
DR CTD; 10201; -.
DR eggNOG; KOG0888; Eukaryota.
DR GeneTree; ENSGT00940000160284; -.
DR OrthoDB; 4638at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 4.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
DR GO; GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0045839; P:negative regulation of mitotic nuclear division; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006228; P:UTP biosynthetic process; IEA:InterPro.
DR CDD; cd04414; NDPk6; 1.
DR Gene3D; 3.30.70.141; Nucleoside diphosphate kinase-like domain; 1.
DR InterPro; IPR034907; NDK-like_dom.
DR InterPro; IPR036850; NDK-like_dom_sf.
DR InterPro; IPR037994; NDPk6.
DR InterPro; IPR001564; Nucleoside_diP_kinase.
DR InterPro; IPR023005; Nucleoside_diP_kinase_AS.
DR PANTHER; PTHR46956; NUCLEOSIDE DIPHOSPHATE KINASE 6; 1.
DR PANTHER; PTHR46956:SF1; NUCLEOSIDE DIPHOSPHATE KINASE 6; 1.
DR Pfam; PF00334; NDK; 1.
DR PRINTS; PR01243; NUCDPKINASE.
DR SMART; SM00562; NDK; 1.
DR SUPFAM; SSF54919; Nucleoside diphosphate kinase, NDK; 1.
DR PROSITE; PS00469; NDP_KINASES; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU004013};
KW Kinase {ECO:0000256|RuleBase:RU004013, ECO:0000313|EMBL:EGV92142.1};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU004013};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transferase {ECO:0000256|RuleBase:RU004013}.
FT DOMAIN 11..152
FT /note="Nucleoside diphosphate kinase-like"
FT /evidence="ECO:0000259|SMART:SM00562"
SQ SEQUENCE 186 AA; 21349 MW; 0A8D5E7F7C65437F CRC64;
MTSILRSPQA LQLTLALIKP DAVAHPLVLE AVHQQILSNK FLIVRMRELQ WKKEDCRRFY
REHEGRFFYQ RLVEFMASGP IRAYILAHKD AIQLWRTLMG PTRVFRARHM APDSIRGSLG
LTDTRNTTHG SDSVVSASRE IAAFFPDFSE QRWYEEEEPQ LRRGPVCYSP EKGIHCVAAT
GSPKPA
//
