ID G3HLL7_CRIGR Unreviewed; 427 AA.
AC G3HLL7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Glial fibrillary acidic protein {ECO:0000256|ARBA:ARBA00018571};
GN ORFNames=I79_011607 {ECO:0000313|EMBL:EGW08196.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW08196.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific
CC marker that, during the development of the central nervous system,
CC distinguishes astrocytes from other glial cells.
CC {ECO:0000256|ARBA:ARBA00002194}.
CC -!- SUBUNIT: Interacts with SYNM. {ECO:0000256|ARBA:ARBA00024375}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; JH000492; EGW08196.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HLL7; -.
DR STRING; 10029.G3HLL7; -.
DR PaxDb; 10029-XP_007635912-1; -.
DR eggNOG; ENOG502RKU6; Eukaryota.
DR InParanoid; G3HLL7; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF9; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 67..375
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 71..219
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 273..346
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 427 AA; 49075 MW; A757381F429E6335 CRC64;
MERRRITSAR RSYASSETVV RGLGPSRHLG TIPRFSLARM PPPLPARVDF SLAGALNAGF
KETRASERAE MMELNDRFAS YIEKVRFLEQ QNKALAAELN QLRAKEPTKL ADVYQAELRE
LRLRLDHLTA NSARLEVERD NLAQDLGTLR QKLQDETNLR LEAENNLAAY RQEADEATMA
RLDLERKIES LEEEIQFLRK VHEEEVRELR EQLAQQQVHV EMDVAKPDLT AALREIRTQY
EAVATSNMQE TEEWYRSKFA DLTDAASRNA ELLRQAKHEA NDYRRQLQAL TCDLESLRGT
NESLERQMRE QDERHARESA SYQEALARLE EEGQSLKEEM ARHLQEYQDL LNVKLALDIE
IATYRKLLEG EENRITIPVQ TFSNLQIRGQ YSGALWERVL NSYLLPQACG LLLGTGGKGI
QVLLGSL
//
