ID G3HLX7_CRIGR Unreviewed; 217 AA.
AC G3HLX7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Homologous-pairing protein 2 homolog {ECO:0000256|ARBA:ARBA00016093};
GN Name=Psmc3ip {ECO:0000313|Ensembl:ENSCGRP00001016763.1,
GN ECO:0000313|RefSeq:XP_035303440.1};
GN ORFNames=I79_011721 {ECO:0000313|EMBL:EGW08049.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW08049.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW08049.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001016763.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_035303440.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_035303440.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_035303440.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HOP2 family.
CC {ECO:0000256|ARBA:ARBA00007922}.
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DR EMBL; JH000499; EGW08049.1; -; Genomic_DNA.
DR RefSeq; XP_003504706.1; XM_003504658.3.
DR RefSeq; XP_007618454.1; XM_007620264.2.
DR RefSeq; XP_035303440.1; XM_035447549.1.
DR STRING; 10029.G3HLX7; -.
DR PaxDb; 10029-XP_007618454-1; -.
DR Ensembl; ENSCGRT00001021007.1; ENSCGRP00001016763.1; ENSCGRG00001017004.1.
DR KEGG; cge:100758855; -.
DR eggNOG; KOG4603; Eukaryota.
DR GeneTree; ENSGT00390000006890; -.
DR OMA; QKYHREW; -.
DR OrthoDB; 25380at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 7.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:Ensembl.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:Ensembl.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IEA:Ensembl.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR010776; Hop2_WH_dom.
DR InterPro; IPR040661; LZ3wCH.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR15938:SF0; HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG; 1.
DR PANTHER; PTHR15938; TBP-1 INTERACTING PROTEIN; 1.
DR Pfam; PF18517; LZ3wCH; 1.
DR Pfam; PF07106; TBPIP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 12..73
FT /note="Homologous-pairing protein 2 winged helix"
FT /evidence="ECO:0000259|Pfam:PF07106"
FT DOMAIN 154..210
FT /note="Leucine zipper with capping helix"
FT /evidence="ECO:0000259|Pfam:PF18517"
FT COILED 86..150
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 217 AA; 24853 MW; 28F857ED4DFC3B91 CRC64;
MSKSRAEAAA GAPGIILRYL QEQNRPYSAQ DVFGNLQKEH GLGKAAVVKA LDQLAQQGKI
KEKTYGKQKI YFADQDQFDI VSDADLHSLD ANIVALTAKV QSLQQSCRHM EAELKELTSA
LTTPEMQKEI QELKKECAHY IERLKNIKAA TNHVTPEERE QVYKEKQKYC KEWRKRKRMT
TDLCDAILEG YPKSKKQFFE EVGIETDEDH NVRLPDP
//
