ID G3HMT7_CRIGR Unreviewed; 582 AA.
AC G3HMT7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Interleukin-22 receptor subunit alpha-1 {ECO:0000313|EMBL:EGW04779.1, ECO:0000313|Ensembl:ENSCGRP00001016633.1, ECO:0000313|RefSeq:XP_027255493.1};
GN Name=Il22ra1 {ECO:0000313|Ensembl:ENSCGRP00001016633.1,
GN ECO:0000313|RefSeq:XP_027255493.1};
GN ORFNames=I79_012078 {ECO:0000313|EMBL:EGW04779.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW04779.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW04779.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001016633.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027255493.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027255493.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027255493.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH000526; EGW04779.1; -; Genomic_DNA.
DR RefSeq; XP_003504982.1; XM_003504934.3.
DR RefSeq; XP_007617197.1; XM_007619007.2.
DR RefSeq; XP_027255493.1; XM_027399692.2.
DR STRING; 10029.G3HMT7; -.
DR PaxDb; 10029-XP_007617197-1; -.
DR Ensembl; ENSCGRT00001020877.1; ENSCGRP00001016633.1; ENSCGRG00001016910.1.
DR KEGG; cge:100756546; -.
DR eggNOG; ENOG502S4IS; Eukaryota.
DR GeneTree; ENSGT00940000161366; -.
DR OMA; WLAKEGC; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042015; F:interleukin-20 binding; IEA:Ensembl.
DR GO; GO:0042018; F:interleukin-22 receptor activity; IEA:Ensembl.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR PANTHER; PTHR20859:SF20; INTERLEUKIN-22 RECEPTOR SUBUNIT ALPHA-1; 1.
DR Pfam; PF09294; Interfer-bind; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EGW04779.1, ECO:0000313|RefSeq:XP_027255493.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..582
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041117323"
FT TRANSMEM 227..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..105
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF01108"
FT DOMAIN 119..197
FT /note="Interferon/interleukin receptor"
FT /evidence="ECO:0000259|Pfam:PF09294"
FT REGION 334..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 63941 MW; AC6D887A2C259060 CRC64;
MKTLLTFLAV GSLAARTTED TACPLQYVKF QSRNFENILV WDSGPDSSPD TVYSVEYKRY
GDRVWLAKAG CQRTTQKSCN LTMETGNLTE LYYARVKAVC PGRKQNNKTT DRFSSLQHTT
IKPPDVTCIP KVRSIQMLIH PTLTPIRSEN GHQLTLEEIF RDLFYRLELR VNHTYQMHLE
GKQREYEFLG LTPDTEFIGA ITILAPMWSK ESAPYVCRVK TLPDRTWAYS FSGAVLFSMG
FLVGLLCYLG YKYVTKPPVP PNSLNVQRVL TFQPLRFIQE HVLIPVLDLS GPSSLTQPIQ
YSQVMISTPR EPPGAAQRHS LPEVTYIGQS DVSTLRPTTN VSPQQTLSPP SYAPKAVPGI
QPPSYAPQVA SDAKTLVYSP QQVMKTHPAT CNSQSILDSW PASYAVCGED TGQDSTPEAL
SSPKHLKPKG QLHEDTLAGS CLPGDLSLQG VTSLAAKETQ RPKSLPPPLE FCTDRGPDLH
ALHSGEPETP GYLKGALSLL SSVQIEGHPV SLPLHTHSLS CSPSDQGPSP WGLLDSLVCP
KDEGPVDEAE AMSPSAAASE LEPPTELDSL FKGLALTVQW EP
//
