ID G3HNP2_CRIGR Unreviewed; 962 AA.
AC G3HNP2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=I79_012384 {ECO:0000313|EMBL:EGW06747.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW06747.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR EMBL; JH000549; EGW06747.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HNP2; -.
DR STRING; 10029.G3HNP2; -.
DR eggNOG; KOG4228; Eukaryota.
DR InParanoid; G3HNP2; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd14557; R-PTPc-C-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016335; Ptprc.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF449; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA; 1.
DR Pfam; PF12567; CD45; 1.
DR Pfam; PF00102; Y_phosphatase; 3.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 281..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 185..276
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 356..615
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 535..606
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 647..885
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 793..876
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 962 AA; 109034 MW; 1556543DABABB32C CRC64;
MHQIPLETGA FLDQTPPAGF SSTLLPHLSP QPDLQTPSAQ GADTQTLSNQ ADLTTLMPAP
DRPDSPDEKF GNIIVYYDYN SNKKSFEAKL KGDKNPQCEA ADCEKLKNLQ ECSQSNFTVS
NGSCIPHKII ELDVPPGTQT NSNEIKLTDL KPQMAYKCSG EILYNNIAFF IKNVSVTTDL
GTPEKPKNLF CGNATENTTL VTWTHPSPLP HGYFSCYNKT NSVLEICDPV GVNDIPYTIK
NLKPYTYYKV SIHAHVTGAV QRNGTAESCS FRTKEAHNAK ALIIFLVFLI IVTSIALLVV
LYKIYDLRKK RSSNLDEQQE LVERDDEKQL MDVEPIHADI LLETYKRKIA DEGRLFLAEF
QSIPRVFSKF SIKDARKPHN QNKNRYVDIL PYDYNRVELS EINGDAGSTY INASYIDGFK
EPRKYIAAQG PRDETVDDFW RMIWEQKATV IVMVTRCEEG NRNKCAEYWP TMEEGTQAFR
DVVVRINEHK RCPDYIIQKL HITHKKEKTT GRDVTHIQFT SWPDHGVPED PHLLLKLRRR
VNAFSNFFSG PIVVHCSAGV GRTGTYIGID AMLEGLEAEG KVDVYGYVVK LRRQRCLMVQ
VEAQYILIHQ ALVEYNQFGE TEVNLSELHS CLQNMKKRDP PSDPSPLEAE FQRLPSYRSW
RTQHIGNQDE NKKKNRNSNV IPYDFNRVPL KHELEMSKES EPDSEASSDD DSDSEETSKY
INASFVMEVC AQYWGEGKQT YGDMEVVMKD TNTSSAYTLR AFELRHSKRK EPRTVYQYQY
TTWSGEELPA EPKNLVSMIQ NLKQKLPKSC PEGMKYHKHS PILVHCRDGS QQTGLFCALF
NLLESAETEE VVDVFQVVKS LRKARTGMVC TYEQYQFLYD VIASTYPAQN GQVKKTNSQD
RIEFHNEVDE AKQDANCVPP ADPLNKTQED GRALGASEPP SGTEEPELSA NGPASPALAQ
SS
//
