ID G3HP37_CRIGR Unreviewed; 1008 AA.
AC G3HP37;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=I79_012541 {ECO:0000313|EMBL:EGV99811.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV99811.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; JH000564; EGV99811.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HP37; -.
DR STRING; 10029.G3HP37; -.
DR PaxDb; 10029-XP_007617150-1; -.
DR eggNOG; KOG0584; Eukaryota.
DR InParanoid; G3HP37; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14032; STKc_WNK2_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024678; Kinase_OSR1/WNK_CCT.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR13902; SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED; 1.
DR PANTHER; PTHR13902:SF10; SERINE_THREONINE-PROTEIN KINASE WNK2; 1.
DR Pfam; PF12202; OSR1_C; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EGV99811.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 196..454
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..111
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 108501 MW; D4B903791636D060 CRC64;
MDHDGGRRDA PGALMEAGRG AGSAGMAEPR ARAARLGPQR FLRRSVVESD QEEPPGLEAA
ETPSSQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA PAAPSDSPGA PSDPGPERAG
TQEPSPDPTT ASAAAEPVPD GGPRQEEEAP APTREIAGAT EAKPEPGRAR KDEPEVEEDD
EDDLKAVATS LDGRFLKFDI ELGRGSFKTV YKGLDTETWV EVAWCELQDR KLTKLERQRF
KEEAEMLKGL QHPNIVRFYD FWESSAKGKR CIVLVTELMT SGTLKTYLKR FKVMKPKVLR
SWCRQILKGL LFLHTRTPPI IHRDLKCDNI FITGPTGSVK IGDLGLATLK RASFAKSVIG
TPEFMAPEMY EEHYDESVDV YAFGMCMLEM ATSEYPYSEC QNAAQIYRKV TCGIKPASFE
KVHDPEIKEI IGECICKNKE ERYEIKDLLS HAFFAEDTGV RVELAEEDHG RKSTIALRLW
VEDPKKLKGK PKDNGAIEFT FDLEKETPDE VAQEMIDSGF FHESDVKIVA KSIRDRVALI
QWRRERIWPA LQSQEPKDSG SPDKAKGLPA PLQVQVTYHA QSGQPGLPEA EEPEADQHLL
PPTLPASVTS LASDSTFDSG QGSTVYSDSQ SSQQSMVLSS LVDTTPTPAS CVCSPPVSEG
PGLTHTLPAL GAFQQPAAVP GLSVGPVPPP ARPALIQQHF PEPSMSFTPV LPPPSTPVPT
GPSQPAPPVQ QVLAPQPVGT VQPVGTVQPV PSHLPPYLPP TSQVVAPAQL KPLQMPQTPL
QPLAQVPPQM PQMPVVPPIT PLAGLDGLPQ TLTDLPAANV APVPPPQYFS PAVILPSLTT
PLPTSPALPL QAVKLPHPPG APLTVPCQTI VPNAPAAIPL LAVAPQGVAA LSIHPAVAQI
PAQLPAQLPA QPVYPAAFPQ LAPGDIPPSP HHTVQSLRAT PPQLASPVPP QPVQPSVVHL
PEQAAPVAAS GTQVIHLWEW TYYSLPGDPQ GQFQETLELF PSEGHGSC
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