ID G3HPS8_CRIGR Unreviewed; 999 AA.
AC G3HPS8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=TC10/CDC42 GTPase-activating protein {ECO:0000313|EMBL:EGW03701.1};
GN ORFNames=I79_012798 {ECO:0000313|EMBL:EGW03701.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW03701.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
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DR EMBL; JH000588; EGW03701.1; -; Genomic_DNA.
DR STRING; 10029.G3HPS8; -.
DR PaxDb; 10029-XP_007622541-1; -.
DR eggNOG; KOG1449; Eukaryota.
DR InParanoid; G3HPS8; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0017053; C:transcription repressor complex; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR028226; LIN37.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF11; RHO GTPASE-ACTIVATING PROTEIN 33; 1.
DR Pfam; PF15306; LIN37; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 366..428
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 471..689
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 29..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 999 AA; 111256 MW; 5247B74C7F101C22 CRC64;
MEMAKARSQL DAVLQCLLDK SHMDRDCSIA ASGKRPSARF PHQRRKKRRE MDDGLAEGGP
QRSNTYVIKL FDRSVDLAQF SENTPLYPIC RAWMRNSPSV RERERERSPS SPLPPLPEDE
EGSEVINSKS RDVYKLPPPT APGPLGDACR SRIPSPLQPE TQGTPDDEPS EPEPSPSTLI
YRNMQRWKRI RQRYINRFRQ AQPTSREERQ PAGATPADFW WLQPNKASLS SSSLSPSDAS
SSSFPINLDG LSPCSVTFNP NANKNSSPKE SVSGGQAPSE DLLAQASRLL QAAEEREGPS
LSGENELVFG VQVTCQMLVP LLLQYLETLS GLVDSNLNCG PVLTWMELDN HGRRLLLSEE
ASLNIPAVAA AHVVKRYTAQ APDELSFEVG DIVSVIDMPP TEDRSWWRGK RGFQVGFFPS
ECVELFTERP EAAVPRPRGK LAGLLRTFMR SRPSRQRLRQ RGILRQRVFG CDLGEHLSNS
GQDVPQVLRC CSEFIEAHGV VDGIYRLSGV SSNIQRLRLT HLPLLDLGLR GHEFDSERIP
ELSGPAFLQD IHSVSSLCKL YFRELPNPLL TYQLYGKFSE AMSVPGEEER LVRVHXXXXX
XXXXHDVIQQ LPPPHYRTLE YLLRHLARMK RHSANTSMHA RNLAIVWAPN LLRSQQLESV
GLGGAAAFRE VRVQSVVVEF LLTHVEVLFS DTFTSAGLDP AGSRPDTVTL RSAKSEESLS
SQASGAGLQR LHRLGRPPPH XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXPVPK LSSLTPRPQA DLTHTPSPS
//
