ID   G3HPZ7_CRIGR            Unreviewed;       638 AA.
AC   G3HPZ7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=All-trans-retinol 13,14-reductase {ECO:0000256|ARBA:ARBA00041141};
DE            EC=1.3.99.23 {ECO:0000256|ARBA:ARBA00038979};
GN   ORFNames=I79_012883 {ECO:0000313|EMBL:EGV93199.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV93199.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol;
CC         Xref=Rhea:RHEA:19193, ChEBI:CHEBI:13193, ChEBI:CHEBI:17336,
CC         ChEBI:CHEBI:17499, ChEBI:CHEBI:52075; EC=1.3.99.23;
CC         Evidence={ECO:0000256|ARBA:ARBA00036004};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911};
CC   -!- COFACTOR:
CC       Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC         Evidence={ECO:0000256|ARBA:ARBA00001937};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC       CrtISO subfamily. {ECO:0000256|ARBA:ARBA00005855}.
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DR   EMBL; JH000593; EGV93199.1; -; Genomic_DNA.
DR   STRING; 10029.G3HPZ7; -.
DR   PaxDb; 10029-XP_007625500-1; -.
DR   eggNOG; KOG4254; Eukaryota.
DR   InParanoid; G3HPZ7; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR46091:SF1; ALL-TRANS-RETINOL 13,14-REDUCTASE; 1.
DR   PANTHER; PTHR46091; BLR7054 PROTEIN; 1.
DR   Pfam; PF13450; NAD_binding_8; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..638
FT                   /note="All-trans-retinol 13,14-reductase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003444559"
SQ   SEQUENCE   638 AA;  70256 MW;  F7C67108D8141208 CRC64;
     MWISVLLLAV LLLAGGXXXX XXXXXXXXXX XXXXXXXXXX XXXXLRRVYV GLFGGSSPNP
     FAEDVKRPPK PLVTDKEARK KVLKQAFSVS RVPGNLDAVV IGSGIGGLAS AAILAKAGKR
     VLVLEQHTKA GGCCHTFGEN GLEFDTGIHY IGRMQEGNIG RFILDQITEG QLDWAPMASP
     FDLMILEGPN GRKEFPMYSG RKQYIQGLKE KFPKEEAVID KYMELVKVVA HGASHAVLLK
     FLPLPLTQLL NKLGLLTHFS PFCRASTESL AEVLQKLGAS RELQAVLSYI FPTYGVTPSY
     TTFSLHALLV DHYIQGAFYP RGGSSEIAFH IIPLIQRAGG AVLTRATVQS VLLDSTGRAC
     GVSVKKGQEL VNIYCPVVIS NAGMFNTYQH LVPESARCLP DVKKQLAMVR PGMSMLSIFI
     CLKGTKEDLK LQSTNYYVYF DTDMDKAMQH YVSMPKEKAP EHIPLLFIAS PSTKDPTWED
     RFPDRSTMTV LVPMAFEWFE EWQEEPKGKR SADYETLKHA FMEASMSVVM KLFPQLEGKV
     ESVTGGSPLT NQYYLAAPRG ATYGADHDLA RLHPRAVASL RAQTPIPNLY LTGQDIFTCG
     LMGALQGALL CSSAILKRNL YSDLQALGSK VQTQKKKE
//