ID G3HQP9_CRIGR Unreviewed; 1490 AA.
AC G3HQP9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Mediator of DNA damage checkpoint protein 1 {ECO:0000256|ARBA:ARBA00015014};
GN Name=Mdc1 {ECO:0000313|Ensembl:ENSCGRP00001000425.1,
GN ECO:0000313|RefSeq:XP_035306818.1};
GN ORFNames=I79_013154 {ECO:0000313|EMBL:EGW09078.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW09078.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW09078.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001000425.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_035306818.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_035306818.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_035306818.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR EMBL; JH000617; EGW09078.1; -; Genomic_DNA.
DR RefSeq; XP_007614152.2; XM_007615962.1.
DR RefSeq; XP_007644560.2; XM_007646370.1.
DR RefSeq; XP_016832809.1; XM_016977320.1.
DR RefSeq; XP_016832810.1; XM_016977321.1.
DR RefSeq; XP_035306818.1; XM_035450927.1.
DR STRING; 10029.G3HQP9; -.
DR PaxDb; 10029-XP_007614152-1; -.
DR Ensembl; ENSCGRT00001000449.1; ENSCGRP00001000425.1; ENSCGRG00001000352.1.
DR GeneID; 100756160; -.
DR KEGG; cge:100756160; -.
DR CTD; 9656; -.
DR eggNOG; KOG2043; Eukaryota.
DR GeneTree; ENSGT00940000161757; -.
DR OrthoDB; 19990at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 1.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR CDD; cd17744; BRCT_MDC1_rpt1; 1.
DR CDD; cd18441; BRCT_MDC1_rpt2; 1.
DR CDD; cd22665; FHA_MDC1; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR23196:SF1; MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1; 1.
DR PANTHER; PTHR23196; PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF16770; RTT107_BRCT_5; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 54..100
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1299..1377
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1490 AA; 158443 MW; 1C42979B8D8F7AE7 CRC64;
MENTQVIDWD AEEEEETEIP SGSLGYSLEP IGQLRLFSST HGPERDFPLY LGKNVIGRSP
DCSVALPFPS ISKQHAVIEI SACNKAPILQ DCGSLNGTQL VKPPKVLTPG VSHRLKDQEL
ILFADFPCQY RRLDVPPPLV SRGLLTIEKT PRIQGGSQTS RVLLAEDSEE EVDFPSGRYV
ANGSRNPTSP SATVVPESDE EGSSPAQSVR GPSLPFDLGS DTDEELCPQP AVGESSSVAR
DGAAAEAKQL EANGVTSGIQ LVLAQPAEQK LRDAKVKSEA GNGAAVVGRG STVGKDSNTE
MGEEHQPSGF VDSDTDVEED RIPVTPPVVP GKKQVLLGVG KKDPGAPVVT HLQDSPAGRG
TGVEEGKTPV AGPPERNHTA MVISSDTDEE DGVSAAVTLA HLKDRGMALW SREPGMEEVK
SQPQVLVERS QSASGKDSDT DVEEEKREVV PDSPMDTDEA LTVPHSESQA PHRASDDVDQ
GVDMGSPGGQ LEGNQASSAT VEDSSAQAGK EVLPPEEAWE TAVEEGSSSA AADVRQSKQP
GVEDAGTEWA ATVCEQASML EVGVQGRSPA TLVEPVVVPT ATLGDPTQPQ REGAQTPTGK
ERGVQMGRTK NAKDCRDAES EDVCLPATQC FVDREGQSSE AVQSLEDEPT QVFPCTLPQE
PGPSHLSLQT PGPGAQDVPW EVLATQPFCL REAEASELQL MDTHPAAHES HPSVSSASAG
QQHLVHTEPL GIEGGEMQTV EKAMGQLSCK MASAGEDSRG DPEPSAHRLL SPVPEASSPP
QSLLTSQSQK PSTPQSLLLT SPPSELHLPE TPHTKPNVRP RRSSRMTSSP HSSAALKPYT
TCPTNLPAAP RPTSRATRGR GRANRSSTRT PEPVVPTDSE LQPPTSTEQS VIPKPTSPVT
QGSINGSFVK TPEPVVLTGP KIQPPTSTEQ PVTPNPTPQA TRGRPHRSSI QTPEPLTPTG
PDLQPPTSTE QPVIPKPTSR AARGRSRKSS TRTPEPAVPT GPDLQPPTST EQPVTPKPTS
RATRGRSRKS VRTPEPAVPT GPDLQLPTST ALGTLGRACK SSIEDSESVG PVASDFEPPI
STDLVAPEVT GQSITLKSSP LSASPVSATS ELQPPVPTAQ PVLLEPIPQA NHRRRRKAAG
KRGSHTVPIG QKPYSAPSEP GSQSSINQGL ALEAAESITV APEPAVSQAP ETSTQNPVVQ
NEAAGRSGLI PKPQPEVSRS RKKPSTTTTS PIQKRPRRQI PQKTIVPKEE DPEEMPVKEE
PQEIAIPTPG KRKRDRVEDE TQGNPSRSRR AKPNQEAAAP KVLFTGVVDS RGERAVLALG
GSLASSVNEA SHLVTDRIRR TVKFLCALGK GIPILSLNWL YQSRKAGHFL PPDDYLVTDP
EQEKNFSFSL RDSLSRARQQ KLLEGYEIYV TPGVQPPPPQ MGEIISCCGG TNLPSMPQSY
KPYRVVITCT EDLPRCAIPS RLGLPLLSPE FLLTGVLKQE VTPEAFVLSN
//
