ID G3HTB2_CRIGR Unreviewed; 2080 AA.
AC G3HTB2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Myosin-XVIIIb {ECO:0000313|EMBL:EGW07183.1};
GN ORFNames=I79_014134 {ECO:0000313|EMBL:EGW07183.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW07183.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; JH000692; EGW07183.1; -; Genomic_DNA.
DR STRING; 10029.G3HTB2; -.
DR PaxDb; 10029-XP_007627367-1; -.
DR eggNOG; KOG0161; Eukaryota.
DR InParanoid; G3HTB2; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01386; MYSc_Myo18; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036064; MYSc_Myo18.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF8; UNCONVENTIONAL MYOSIN-XVIIIB; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 483..1217
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 1..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1092..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1298..1328
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1357..1671
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1786..1855
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1911..1952
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 572..579
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2080 AA; 232452 MW; CEEEBFB55F59C1F3 CRC64;
MRTPEVPINQ ANKTNNVPKP GSQQTSQDSP SATQKDADIP GKDPPRADDK NSMPVTSTGG
EKPQESGPTG TPAKRTLPFK RGVRRGDVLL MVAKLDPELA KPEQKTQPRD TPKDKTPALA
TDPGGTKKGA TTGTPCGPQT PITEKNSTGG DGDTSQGGTK GGKCQGTEGK GSRDPQTKGQ
KECESQNTEG QGTRSPAWEA VNKGQVGTVE KGGGGPPKKM EKEDGPKGAG AKVRPLEPPV
PIKKWGVSLG RRSKWDSSQS KNRESESQRR DEKRGDLQGT AAEPRGQQQE APGKMEKAGG
SQKKLVIPGK CQEQPGVTAE TQSPQECCKA PGGMPTEVTL AAEVAEAARR EDQPESTAQG
AGEPCVHAEE EVDIEEPQAE GPVESLPKTQ VERSSLQKPM EEEPVLQDPG RDSDQASEED
RWYEAQKVWL VQKDGFTLAT VLKPDEGTAD LPAGRVRLCM DADKTVTEVD EDQVHRANPS
ELDQTEDLAS LVCVNESSVL NTLLQRYQAQ LPHTRSGPDL IALQPQKTTV PSSGKVPRGR
QDGLPAHVTS LAQRAYWALL SQRRDQSIVA LGRSGAGKTT CCEQVLEHLV SMAGSVDGRV
SVEKLQAAFT VLQAFGSVST GHSRRASRFS MVISLDFNAT GRVTAAQVQT VLLENSRVAR
QPQGEGNFEV FSQLLAGLDV DLRTELNLHQ MSESNAFGMG VWSQPEDKQK AATAFSQLQG
AMELLGISEG EQRAIWRVLA AIYHLGAAGA CKVGRKQFMR FEWANHAAEA LGCDYEELNT
ATFKHHLRQI IEQMTSGSQR QCLEDNDASS GLKMTGVECV EGMASGLYQE LFGAVVYLIN
RAFSSHHLSM ASIMVVDSPG FQNPRHQCKD RAATFEELCY NYAQERLQLL FYHRTFVSTL
ERYQEAHLPA GGATEAAGGL FWVLDEEVRV EGSSDSVVLE RLCAAFEKKT VGADGPSVLR
ICEQPLQCEL FHQLGRDPVR YDLTGWLRRA KPNLSALEAP QILQQSQRKE LQNLFQARAK
LPPVCRAVAG LEGTSQQALH RGRVVRRAFA SRVAALKRKA PCAQIKLQMD ALISLLSRSQ
LHFIHCLVPT SVESKPGQGT PSPPQPGGDQ GGANEPPALD IPAMRVQLAG SHILEALRLH
RAGYADHMGL VQFRRRFQAL DPQLLKKLDW TSEGLDERKV VEELLQTLDL EKKAVAVGHS
QVFLKAGVVS RLERQREKLV SQNIVLFQAA CRGFLSRQEC KKLKAGGPPC THILLLQIRR
LATQCIQKNL TVFLEVKDWP WWRLLASLRP LLSPTLSLEQ LQAKEEELTL LREKLQKSEK
SRSELRQSTD LLESKITDLI SELADERFKG DVACQALESE RAERLQAFRE VQELKAKYQQ
VQEALGAVQK QLEEAQQKIQ LANLEEKHTG GADEWQMRLD CAQMENDFLR KRLQQCEERL
DSEMKARTEV EQKLGELQNA YEEAKKTAHQ LKRKCHHLTW DLEDTRVLLE NQQSRNHELE
KRQKKFDLQL AKALGESMFE KTLREKVSQE NSGVRWELGQ LQQQLEQKEQ EASKLKQEVE
KLQGQKQELL GCASVGKQGV ASLKEKVWEL ESSALEQQKV HSQQENTIKQ LEQLRQRFEL
EIERMKQMHQ KDREDQEEEL EDVRQSCQKR LRQMEMQLEQ EHEEKQVALH EKRDLEGLIG
TLCDQIGHRD FDVEKRLRRD LRRTHALLSD VQLLLATMED SKTSVSKEEL EKVHSQLEQS
EAKCEDALKT QKVLTTDLEN MHSELETVAR SKSVVDEQLY RLQFERADLL KRIDEDQEDL
NGLMQKHKDL IAQSAADIGQ IQELQLQLEE AKKEKQKLQE QLQVAQLRIQ YLEQSTVDRA
IVSRQEAVIC DLENKTEFQK VLMKRFEVLV IRLRNSLIKM GEELSQTSKS EAQQRENSQY
YQRRLEELKA EMKELMQREE EASRRCMELE KYVEELAAVR QTLQVDLETS IRRIADLQAA
LEDVVSSDSD TESVQTAVDC GSRRRKEEDN VSVISSQPES SLQSWMSCSL SLAMDTARAP
SQQSVVSSSL LSPRPSQGGC YALCVIAVHL SVKHTQSRKA
//
