ID   G3HTV1_CRIGR            Unreviewed;      1126 AA.
AC   G3HTV1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Protein unc-13-like D {ECO:0000313|EMBL:EGW04663.1};
GN   ORFNames=I79_014331 {ECO:0000313|EMBL:EGW04663.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW04663.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SIMILARITY: Belongs to the unc-13 family.
CC       {ECO:0000256|ARBA:ARBA00005823}.
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DR   EMBL; JH000721; EGW04663.1; -; Genomic_DNA.
DR   AlphaFoldDB; G3HTV1; -.
DR   STRING; 10029.G3HTV1; -.
DR   PaxDb; 10029-XP_007615877-1; -.
DR   eggNOG; KOG1328; Eukaryota.
DR   InParanoid; G3HTV1; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   CDD; cd08676; C2A_Munc13-like; 1.
DR   CDD; cd04009; C2B_Munc13-like; 1.
DR   Gene3D; 1.10.357.50; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR010439; MUN_dom.
DR   InterPro; IPR014770; Munc13_1.
DR   InterPro; IPR014772; Munc13_dom-2.
DR   PANTHER; PTHR45999:SF3; PROTEIN UNC-13 HOMOLOG D; 1.
DR   PANTHER; PTHR45999; UNC-13-4A, ISOFORM B; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF06292; MUN; 1.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS51258; MHD1; 1.
DR   PROSITE; PS51259; MHD2; 1.
PE   3: Inferred from homology;
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT   DOMAIN          80..228
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          573..693
FT                   /note="MHD1"
FT                   /evidence="ECO:0000259|PROSITE:PS51258"
FT   DOMAIN          804..931
FT                   /note="MHD2"
FT                   /evidence="ECO:0000259|PROSITE:PS51259"
FT   DOMAIN          946..1071
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1069..1092
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1126 AA;  126624 MW;  2BC4575997926038 CRC64;
     MDLRHARPGD EKNDPGVSPS GSLMLEQVQV QSHHFSSEER DLLYEEALYT VLHRLGQPEP
     NHVKEASELL RYLQEAFQVQ PEEHQQMLQR VGELEKPIFC LKATVKQAKG ILGKDVSGFS
     DPYCLLGIIE QGAGIAEGSP VSRRRQKAVV KHTIPEEQTH RTQVKNQTLN PVWDETFVLE
     FEDITNASFH LDMWDLDTVE SVRQKLGELT DLHGLRRIFK EARKDKGQDD FLGNVVLRLQ
     DLRCRQDQWY PLEPCTETYP DRGQCHLQFQ FIHKRRATVA SRSQPSYTVH FHLLQQLVSH
     EVTQHQAGSA SWDASLSPQG ATILFLHATQ KDLSDFHQSM AQWLGYSPPH QSLEFPSSCL
     LHPITSMEYQ WIQGRLRAEQ REELAASFTS LLTYGLSLIR KFRSVFPLSV SDSPSRLQSL
     LRVLVQMCKT KAFGELCPDS APLSQLVSEA LRVGIFPRVG GGHIPELNNP SSSLPVFQQT
     GTVEWFHLMQ QHHQPMVQGI LEAGKALLSL VQDVMGDLYQ CRHTWNKIFH NVLKIDLFSV
     AFLELQWLVA KRVQDHTAEA GKLVSPDMGE ILFQLYVSLK EISQLGPGPS SSNGVLALDG
     FHRWFQPAIP SWLQKTYSVA LERVQRAVRM DSLVPLGELT KHSTSAVDLS TCFAQISHTA
     RQLDWPDPEE AFMITVKFVE DTCRLALVYC SLIKARAREL STGQKDQGQA ANMLCVVVNN
     MEQLRLIIDK LPTQLAWEAL EQRVGAVLEQ GQLHNTLHAQ LQGTLAGLGH EIRTGVRTLA
     EQLEVGIATH IQKLIGVKES VLPEDAILPL MKFLEVKLRY MNTNLVQENF SSIFASSPIL
     PFCVRHRLPL ASLLTLLWTH TLTVLVEVAS SQRSSLLASS RLKAALQNLE ICFHAEGCGL
     PPEALHTATF QALQRDLELQ SASSRELIQK YFCSRIQQQA ETTSEQLGAV TIKASYRASE
     QKLRVELLSA SSLLPLDSNG SSDPFVQLTL EPRHEFPELA PRETQKHKKE LHPLFDETFE
     FLVPAEPCQK DWACLLLTVL DHDTLGADDL EGEAFLPLCR VPGLTGCEEP GEAPQTRLPL
     TYPAPNGDPI LQLLDSRKGD REAQAFVKLR RQRAKQASQH APRPAQ
//