ID G3HUJ6_CRIGR Unreviewed; 913 AA.
AC G3HUJ6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Trafficking kinesin protein 2 {ECO:0000313|Ensembl:ENSCGRP00001016882.1};
DE SubName: Full=Trafficking kinesin-binding protein 2 {ECO:0000313|EMBL:EGV99434.1, ECO:0000313|RefSeq:XP_027252777.1};
GN Name=Trak2 {ECO:0000313|Ensembl:ENSCGRP00001016882.1,
GN ECO:0000313|RefSeq:XP_027252777.1, ECO:0000313|RefSeq:XP_027252778.1,
GN ECO:0000313|RefSeq:XP_027252779.1};
GN ORFNames=I79_014608 {ECO:0000313|EMBL:EGV99434.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV99434.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV99434.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001016882.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027252777.1, ECO:0000313|RefSeq:XP_027252778.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027252777.1,
RC ECO:0000313|RefSeq:XP_027252778.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027252777.1,
RC ECO:0000313|RefSeq:XP_027252778.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the milton family.
CC {ECO:0000256|ARBA:ARBA00007007}.
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DR EMBL; JH000741; EGV99434.1; -; Genomic_DNA.
DR RefSeq; XP_003507074.1; XM_003507026.3.
DR RefSeq; XP_007645750.1; XM_007647560.2.
DR RefSeq; XP_027252777.1; XM_027396976.2.
DR RefSeq; XP_027252778.1; XM_027396977.2.
DR RefSeq; XP_027252779.1; XM_027396978.2.
DR STRING; 10029.G3HUJ6; -.
DR PaxDb; 10029-XP_007645750-1; -.
DR Ensembl; ENSCGRT00001021126.1; ENSCGRP00001016882.1; ENSCGRG00001017078.1.
DR GeneID; 100756850; -.
DR KEGG; cge:100756850; -.
DR CTD; 66008; -.
DR eggNOG; KOG4360; Eukaryota.
DR GeneTree; ENSGT00940000158202; -.
DR OMA; LDGSHKF; -.
DR OrthoDB; 2909788at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 2.
DR GO; GO:0032839; C:dendrite cytoplasm; IEA:GOC.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0098972; P:anterograde dendritic transport of mitochondrion; IEA:Ensembl.
DR InterPro; IPR006933; HAP1_N.
DR InterPro; IPR022154; TRAK1/2_C.
DR PANTHER; PTHR15751; TRAFFICKING KINESIN-BINDING PROTEIN; 1.
DR PANTHER; PTHR15751:SF13; TRAFFICKING KINESIN-BINDING PROTEIN 2; 1.
DR Pfam; PF04849; HAP1_N; 1.
DR Pfam; PF12448; Milton; 1.
DR SMART; SM01424; HAP1_N; 1.
DR SMART; SM01423; Milton; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 48..353
FT /note="HAP1 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01424"
FT DOMAIN 414..565
FT /note="Trafficking kinesin-binding protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01423"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 133..167
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 203..332
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..787
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 913 AA; 101513 MW; D6FE02B91CE9F49E CRC64;
MSQSQNAIFT SPTGEENLMN SNHRDSESIT DVCSNEDLPE VELVNLLEEQ LPQYKLRVDS
LFLYENQDWA QSSHQPQDAP ETLSPVLAEE TFRYMILGTD RVEQMTKTYN DIDMVTHLLA
ERDRDLELAA RIGQALLKRN HVLSEQNEAL EEQLGQAFDQ VNQLQHELSK KDELLRIVSI
ASEESETDSS CSTPLRFNES FSLSQGLLQL DMLHEKLREL EEENMALRSK ACHIKTETFT
YEEKEQQLVN DCVKELRETN AQMSRMTEEL SGKSDELIRY QEEISSLLSQ IVDLQHKLKE
HVIEKEELRL HLQASKDAQR QLTMELHDLQ DRNMECLGML HESQEEIKEL RSKCGPAAHL
CFSQSYGLFT GESLAAEIEG TMRKKLSLDE ESVFKQKAQQ KRVFNTVKVA NDTRGRSVTF
PALLPIPGSN RSSVIMTAKP FESGVQQTED NTLLNRGGST EEVPGNSRPI SHPGPTEDSD
LATALHRLSL RRQNYLSEKQ FFAEEWERKI QVLAEKEGIG SCDSPTRNLD SFSTDQSETT
DLGSASCLRG FMPEKLQIVK PLEGSQTLHH WQQLAQPNLG TILDPRPGVI TKGFTQMPTD
VVYHISDLEE DEEEGITFQV QQPLQLEQKP AAPTPVTGIF LPPITSAGGP VTVATSNPGK
CLSCTNSTFT FTTCRILHPS DITQVTPSSG FPSLSSGSSG SSSSNTAVNS PAMSYRLSIG
ESITNRRDST ITFSSTRSLA KLLQERGISA KVYHSPASEN PLLQPRPKAL ATPSTPPNSP
SQSPCSSPLP FEPRVHVSEN FLASRPAETF LQEMYGLRPS RAPPDVGQLK MNLVDRLKRL
GIARVVKTPD PQESGKSREA EVALQKADSA VYLNSSGSLL GGLRRNQSLP IMMASFGAPV
CTTSPKMGIL KED
//
