ID G3HV54_CRIGR Unreviewed; 721 AA.
AC G3HV54;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN ORFNames=I79_014831 {ECO:0000313|EMBL:EGV95377.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV95377.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR EMBL; JH000760; EGV95377.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HV54; -.
DR STRING; 10029.G3HV54; -.
DR PaxDb; 10029-XP_003507259-1; -.
DR InParanoid; G3HV54; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF36; INTEGRIN BETA-7; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 2.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..721
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003444684"
FT TRANSMEM 648..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..92
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 50..474
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 564..643
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 668..714
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT REGION 92..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 51..61
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 54..91
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 64..80
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 216..223
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 271..311
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 412..426
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 446..609
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 472..476
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 486..498
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 495..535
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 500..509
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 511..525
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 541..546
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 543..572
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 548..557
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 559..564
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 721 AA; 78772 MW; 6AE6D6F17CEFA7FD CRC64;
MVDSSTVLVF LLLLCGGESE SDTKVPSLEE ATEWGHTDLS QSGSCQPAPS CQKCILSHPS
CAWCKQLNFT VSGEAEERRC ARREELLARG CPAQELEEPR GHQEVLQDKP LSQGDRGEGA
TQLAPQRVRV TLRPGEPQKL RVRFLRAAGY PVDLYYLMDL SYSMKDDLER VRQLGHALLV
RLQEVTHSVR IGFGSFVDKT VLPFVSTVPS KLQHPCPSRL ERCQRPFSFH HVLSLTGDAQ
AFEREVGRQN ISGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL
GGIFMPSDGR CHLDSNGVYI HSAEFDYPSV GQVAQALTAA NIQPIFAVTG TTLPVYQELS
QLIPKSAVGE LSEDSSNVVQ LIMDAYDSLS STVTLEHSSL PPGVNISFES HCPEKREGEA
GNRGQCSNVR VNQTVDFWVT LQVTHCLPEP HLLRFWALGF SEELTVELHT LCDCNCSDTQ
PHAPYCSNGQ GHLLCGICSC VPGRLGQLCE CSEAELSSPD LESGCRAPNG TGPLCSGKGR
CQCGRCSCSG QSSGRLCECD DASCERHEGI LCGECGAFGT GPLAVNCSVA CADVNVTVAM
VPNLDDGWCK ERTQDNQLFF FLVEHVAEGV ILRVRPQEKG AADHTRTIIL GCIGGIVAVG
LGLVLAYRLS VEIYDRREYS RFEKERQQLN WKQDSNPLYK SAITTTINPR FQETNGPGPS
L
//
