ID   G3HV64_CRIGR            Unreviewed;       368 AA.
AC   G3HV64;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Left-right determination factor {ECO:0000256|PIRNR:PIRNR037402};
GN   ORFNames=I79_014841 {ECO:0000313|EMBL:EGW11173.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW11173.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR037402}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR037402,
CC       ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; JH000761; EGW11173.1; -; Genomic_DNA.
DR   RefSeq; XP_003507278.1; XM_003507230.1.
DR   AlphaFoldDB; G3HV64; -.
DR   STRING; 10029.G3HV64; -.
DR   PaxDb; 10029-XP_007626415-1; -.
DR   GeneID; 100751951; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   InParanoid; G3HV64; -.
DR   OMA; SCAWDGV; -.
DR   OrthoDB; 5391376at2759; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR   CDD; cd13758; TGF_beta_LEFTY1_2; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR003942; LRDF.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF175; LEFT-RIGHT DETERMINATION FACTOR 2; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   PIRSF; PIRSF037402; TGFb4; 1.
DR   PRINTS; PR01427; TGFBETA4.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Cytokine {ECO:0000256|PIRNR:PIRNR037402};
KW   Developmental protein {ECO:0000256|PIRNR:PIRNR037402};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|PIRNR:PIRNR037402};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037402};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..368
FT                   /note="Left-right determination factor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003444628"
FT   DOMAIN          232..356
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   368 AA;  41528 MW;  0A5026F6ED23908D CRC64;
     MQSLWLCWVL WALALAGCGA AVTEEQILVK LLQQLQLSRA PVLDNVDVET MAIPAHVRAQ
     YVSLLHRSHG DRSRGKRFSQ NFREVAGRFL VSETSKHLLV FGMEQRLPPN SELVQAVLRL
     FQEPVPRTAL RRHERLSPHS ARARVTIEWL RVREDGSNRT ALIDSRLVSI HESGWKAFDV
     TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP GTWSAHKLVR FAAQGIPGRE GRGEPQLELH
     TLDLKDYGAQ GNCNPETPVT EGTRCCRQEM YLDLQGMKWA ENWILEPPGF LVYECVGSCL
     QLPESLTIKW PFLGPRQCIA SEMTSLPVIV SMKEGGRTRP QVVSLPNMRV QRCSCVSDGA
     LVPRGIDL
//