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Database: UniProt
Entry: G3HVA5_CRIGR
LinkDB: G3HVA5_CRIGR
Original site: G3HVA5_CRIGR 
ID   G3HVA5_CRIGR            Unreviewed;       375 AA.
AC   G3HVA5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUN-2019, entry version 44.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 15 {ECO:0000313|EMBL:EGW12237.1};
DE   SubName: Full=KCNJ15 {ECO:0000313|EMBL:RLQ67213.1};
GN   ORFNames=CgPICR_016377 {ECO:0000313|EMBL:RLQ67213.1}, I79_014885
GN   {ECO:0000313|EMBL:EGW12237.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW12237.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
RN   [2] {ECO:0000313|EMBL:EGW12237.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:RLQ67213.1, ECO:0000313|Proteomes:UP000273346}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17A/GY {ECO:0000313|EMBL:RLQ67213.1,
RC   ECO:0000313|Proteomes:UP000273346};
RC   TISSUE=Liver {ECO:0000313|EMBL:RLQ67213.1};
RX   PubMed=29704459; DOI=10.1002/bit.26722;
RA   Rupp O., MacDonald M.L., Li S., Dhiman H., Polson S., Griep S.,
RA   Heffner K., Hernandez I., Brinkrolf K., Jadhav V., Samoudi M., Hao H.,
RA   Kingham B., Goesmann A., Betenbaugh M.J., Lewis N.E., Borth N.,
RA   Lee K.H.;
RT   "A reference genome of the Chinese hamster based on a hybrid assembly
RT   strategy.";
RL   Biotechnol. Bioeng. 115:2087-2100(2018).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; JH000767; EGW12237.1; -; Genomic_DNA.
DR   EMBL; RAZU01000170; RLQ67213.1; -; Genomic_DNA.
DR   SMR; G3HVA5; -.
DR   STRING; 10029.XP_007634329.1; -.
DR   PRIDE; G3HVA5; -.
DR   InParanoid; G3HVA5; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   Proteomes; UP000273346; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003270; K_chnl_inward-rec_Kir1.3.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF20; PTHR11767:SF20; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01323; KIR13CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075,
KW   ECO:0000313|Proteomes:UP000273346};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:EGW12237.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     67     88       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    142    166       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       30    171       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      178    348       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   COILED      348    368       {ECO:0000256|SAM:Coils}.
FT   SITE        157    157       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   375 AA;  42622 MW;  7AC10AC7C56FE4E7 CRC64;
     MDTIHIGMSS APLVKHSNGV GLKAHRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID
     MKWRYKLTLF AATFVMTWFL FGVVYYAIAF IHGDLELGES NSNHTPCIMK VDSLTGAFLF
     SLESQTTIGY GVRSITEECP HAIFLLVAQL VITTLIEIFI TGTFLAKIAR PKKRAETIKF
     SHCAVISKQN GKLCLVIQVA NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD
     SSSESPFLIL PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY
     IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQK LEEQYRQEDQ
     RERELRSLLL QQSNV
//
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