ID G3HWN8_CRIGR Unreviewed; 987 AA.
AC G3HWN8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Zinc fingers and homeoboxes protein 3 {ECO:0000313|EMBL:EGV93098.1};
GN ORFNames=I79_015399 {ECO:0000313|EMBL:EGV93098.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV93098.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the ZHX family. {ECO:0000256|ARBA:ARBA00007440}.
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DR EMBL; JH000836; EGV93098.1; -; Genomic_DNA.
DR RefSeq; XP_007646462.1; XM_007648272.2.
DR RefSeq; XP_016833749.1; XM_016978260.1.
DR AlphaFoldDB; G3HWN8; -.
DR STRING; 10029.G3HWN8; -.
DR PaxDb; 10029-XP_007616459-1; -.
DR eggNOG; ENOG502RC6G; Eukaryota.
DR InParanoid; G3HWN8; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 4.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 5.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR024578; Homez_homeobox_dom.
DR InterPro; IPR041057; ZHX_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR15467:SF6; ZINC FINGERS AND HOMEOBOXES PROTEIN 3; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF00046; Homeodomain; 3.
DR Pfam; PF11569; Homez; 1.
DR Pfam; PF18387; zf_C2H2_ZHX; 1.
DR SMART; SM00389; HOX; 4.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 5.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 319..362
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 501..551
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 621..669
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 771..821
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 321..363
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 503..552
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 623..670
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 773..822
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 24..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 107918 MW; DD543268A44BE3C2 CRC64;
MASKRKSTTP CMIPVKTVVL QGASTEAQPV DTLPEGPQQD LPSEAPAASS EAVPNPSSTD
GSALANGHRS TLDGYVYSCK DCDFRSQDMT QFVGHMNSEH TDFNKDPNFV CTGCNFLAKT
PEGLSLHNAK CHSGEASFLW NVTKPDNHMV VEQNVPESPG TCDLAGESAT EGIDGQAEII
ITKTPIMKIM KGKAEAKKIH MLKENAPNQP VGEALPKPLT GEAEVKEGDH TFANGAAPVS
QASASSSKPP HAANGPLIGT VPVLPAGIAQ FLSLQQQPPV HAQHHTHQPL PTSKALPKVM
IPLSSIPTYN AAMDSNSFLK NSFHKFPYPT KAELCYLTVV TKYPEEQLKI WFTAQRLKQG
ISWSPEEIED ARKKMFNTVI QSVPQPTITV LNTPLVASTG NVQHLIQAAL PGHVVGQPEG
TAGGLLVTQP LMTNGLQGSS SSLPLTTASV PKSTVAPINT VCSNTTSAVK VVNAAQSLLT
ACPSITSQAF LDANIYKNKK SHEQLSALKG SFCRNQFPGQ SEVEHLTKVT GLSTREVRKW
FSDRRYHCRN LKGSRTMMPG EHGSVLIDSV PEVPFPLSSK VPEVTCIPTT TSLASHPATK
RQSWHQTPDF TPTKYKERAP EQLRVLESSF AQNPLPPEEE LDRLRSETKM TRREIDGWFS
ERRKKVNAED TKKAEGQVYQ EEEEGAEVEG GDEELASELR VLGENGSPEM FLSHTLAERK
VSPIKINLKN LRVTEASGKN ELPGLGVCET EEDGLNKLVE QPPGKVSYKK TAQQRHLLRQ
LFVQTQWPSN QDYDSIMAQT GLPRPEVVRW FGDSRYALKN GQLKWYEDYK RGNFPPGLLV
IAPGNRELLQ DYYMTHKMLC EGDLQTLCDK TQMSAQQVKQ WFAEKMGEET RAVADTSSED
KGPGTGEPVA VHRVLGDAYS EMSENSESWE PSAPEASSEP FDTLSPQSGR QLGKGLMGFM
HDFPLNLRED TVTEWAQGAG TVASKAT
//
