ID G3HWV1_CRIGR Unreviewed; 302 AA.
AC G3HWV1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Forkhead box R2 {ECO:0000313|Ensembl:ENSCGRP00001006803.1};
DE SubName: Full=Forkhead box protein R2 {ECO:0000313|EMBL:EGW13364.1, ECO:0000313|EMBL:ERE65380.1, ECO:0000313|RefSeq:XP_027287821.1};
GN Name=Foxr2 {ECO:0000313|Ensembl:ENSCGRP00001006803.1,
GN ECO:0000313|RefSeq:XP_027287821.1};
GN ORFNames=H671_xg20294 {ECO:0000313|EMBL:ERE65380.1}, I79_015464
GN {ECO:0000313|EMBL:EGW13364.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13364.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW13364.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000030759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17A/GY {ECO:0000313|Proteomes:UP000030759};
RX PubMed=23929341; DOI=10.1038/nbt.2645;
RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B., Kofler R.,
RA Romand S., Hesse F., Budach W.E., Galosy S., Muller D., Noll T.,
RA Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A., Goesmann A.,
RA Helk B., Mott J.E., Puhler A., Borth N.;
RT "Chinese hamster genome sequenced from sorted chromosomes.";
RL Nat. Biotechnol. 31:694-695(2013).
RN [4] {ECO:0000313|EMBL:ERE65380.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=17A/GY {ECO:0000313|EMBL:ERE65380.1};
RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B., Kofler R.,
RA Romand S., Hesse F., Budach W.E., Galosy S., Muller D., Noll T.,
RA Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A., Goesmann A.,
RA Helk B., Mott J.E., Puehler A., Borth N.;
RT "Chinese hamster genome sequenced from sorted chromosomes.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSCGRP00001006803.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:XP_027287821.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027287821.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027287821.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; JH000840; EGW13364.1; -; Genomic_DNA.
DR EMBL; KE684630; ERE65380.1; -; Genomic_DNA.
DR RefSeq; XP_003507784.1; XM_003507736.2.
DR RefSeq; XP_007627743.1; XM_007629553.2.
DR RefSeq; XP_027287821.1; XM_027432020.2.
DR STRING; 10029.G3HWV1; -.
DR PaxDb; 10029-XP_007627743-1; -.
DR Ensembl; ENSCGRT00001010739.1; ENSCGRP00001006803.1; ENSCGRG00001009252.1.
DR GeneID; 100764480; -.
DR KEGG; cge:100764480; -.
DR CTD; 139628; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000162993; -.
DR OMA; FFWTAPD; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000030759; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome X.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR CDD; cd20036; FH_FOXR; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46789; FORKHEAD BOX PROTEIN R1; 1.
DR PANTHER; PTHR46789:SF2; FORKHEAD BOX PROTEIN R2; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 183..266
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 183..266
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 156..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 35105 MW; D224D76CFDC693F3 CRC64;
MDVKLKDRDF WYSLHGQVPG MLEWDMGNEF FLPCTTDQRP FAEQSLAKYK IQLLKPPALP
QERKANTDED DPLTEPSLWM WVNPNIVCPI NSNEAPNPSH KVQPSVPVPK TDESAFLGAQ
RVMQSLSVLH TEHCQPQKLS VSSSDPDFIN EEIEEQECTS SNRYPKKHTL HHGPHQDRES
WPRPPLNYSH LVALALKSSP SCGLNVQQIY NFTRQHFPYF RTAPEGWKNT IRHNLCSLTC
FEKVPVDMEE EQDDKPRSFI WKLTDEGHRF FQEDTRVLAC ARRESIKQCM RQPELIDLLF
HL
//
