ID G3HXU6_CRIGR Unreviewed; 846 AA.
AC G3HXU6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=SH3 domain-containing guanine exchange factor {ECO:0000313|EMBL:EGW13186.1};
GN ORFNames=I79_015860 {ECO:0000313|EMBL:EGW13186.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13186.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
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DR EMBL; JH000893; EGW13186.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HXU6; -.
DR STRING; 10029.G3HXU6; -.
DR PaxDb; 10029-XP_007627052-1; -.
DR eggNOG; KOG3523; Eukaryota.
DR InParanoid; G3HXU6; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11938; SH3_ARHGEF16_26; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035797; ARHGEF16/ARHGEF26_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12845:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 414..598
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 630..757
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 764..825
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 94711 MW; F47B24E3D9BEA6C4 CRC64;
MDSESEVDFS SNGVTPLWRR RSTPPLQLLG RSKPRPQSYQ SPSGLLITDF PVEELAALPV
PQTPSRVSAA PDGRMVSRSP QLLCPHRRPV TNGRSVSPDY RAASPRLRRP KSPLVLHAAS
GGSPKPSANG TVASSAALLG ASRTPDAPDP EEDRTVVTAS KVSSPIANGL VPKNDSPGSA
SLTGQTARDL EPGSSRLSPA PQHRSSEQKL PLQRLPSQGN ELPNPSVVLS TNSPAALKMG
KQQIIPKSLA SEIKLSKSNS QNVEPHRRLL KVRSMVEGLG APLGHEGEEG EVDNDLDSPG
SLRRGLRSTS YRRAVVSGFD FDSPTSSKKK NRMSQPVLKA VMEDKEKFSS LGRIKKKMLK
GQGTFDGEEN AVLYQNYKEK ALDIDSDEES EPKEQKPEEK IVIHHKPLRS TWSQLSAAIF
EVISSEHSYL LSLEILIRMF KDSKELSDTM TKTERHHLFS NITDVCEASK KFFTELEARH
QNNILIDDIS DIVEKHTAST FDPYVKYCTN EVYQQRTLQK LLATNPSFKE VLSRIESHED
CRNLPMISFL ILPMQRVTRL PLLMDTICQK TPKDSPKYEV CKRALKEVSK LVRLCNEGAR
KMERTEMMYT INSQLEFKIK PFPLVSSSRW LVKRGELTAY VEDTVLFSKR MSRQQVYFFL
FNDVLIITKK KSEESYNVND YSLRDQLLVE SCDNEELNSS PGKNTSTMLY SRQSSATHLF
TLTVLSNHAN EKVDMLLGAE TQSERARWIT ALGHSSGKQP PDRTTLTQVE IIRSFTAKQP
DELSLQVADV VLIYQRVGDG WYEGERLRDG ERGWFPMECA KEITCQATID KNVERMGRLL
GLETNV
//
