ID G3HY01_CRIGR Unreviewed; 813 AA.
AC G3HY01;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Sushi domain-containing protein 2 {ECO:0000313|EMBL:EGW12150.1};
GN ORFNames=I79_015926 {ECO:0000313|EMBL:EGW12150.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW12150.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; JH000899; EGW12150.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HY01; -.
DR STRING; 10029.G3HY01; -.
DR PaxDb; 10029-XP_007619958-1; -.
DR eggNOG; KOG4291; Eukaryota.
DR InParanoid; G3HY01; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 1.
DR Gene3D; 4.10.410.20; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR005533; AMOP_dom.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR13802; MUCIN 4-RELATED; 1.
DR PANTHER; PTHR13802:SF63; SUSHI DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF03782; AMOP; 1.
DR Pfam; PF00084; Sushi; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00723; AMOP; 1.
DR SMART; SM00032; CCP; 1.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 1.
DR PROSITE; PS50856; AMOP; 1.
DR PROSITE; PS50958; SMB_2; 1.
DR PROSITE; PS50923; SUSHI; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..813
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003444593"
FT TRANSMEM 781..805
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..64
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 282..430
FT /note="AMOP"
FT /evidence="ECO:0000259|PROSITE:PS50856"
FT DOMAIN 442..636
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 720..777
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 748..775
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 813 AA; 89832 MW; 708EDBBBDD5EA581 CRC64;
MKLALLPWIL MLLVTIPGPR LTAGARGSCS LRCGEQGGPC SCHPTCSGLG TCCEDILNYC
LEISPSSGSM MGGKDFVVQH LVWHGSTDRV ICRFKDSVQT LGYVDNLNRV HCISPLLYES
GHIPFTISLD NGRSFPHAGT WLAAHPYKVS ESEKSQLVNE TRWQYYGTSD TSGDLSLTWN
TSLLPVQTVT IELWGYEETG KPYSDNWTAK WSYLYSLTRN TPNSGFFTFK PKPASPEYQR
WRVGALRISS SRNYEGQQDV LALWTNDHAL AWHLGDDFRA DSVAWAREQC LAWEALEDQL
PNFLKELPDC PCTLAQARAD SGRFFTDYGC DIEQGSVCTY HPGAVHCVRS VQASPRYGSG
QQCCYTAAGT QLLTSDSTSG STPDRGHDWG APPYRTPPRV PGMSHWLYDV MSFYYCCLWA
PECSRYMKRR PSSDCRSYRP PRLASAFGDP HFVTFDGTSF SFSGSGEYVL IKATLTDLRV
QGRTLPGKMP NGTQAHGTGL IAVAVQEDNS DVVEVRLANG PQALQVLLNQ KALSFTEQNW
MDLKGMFLSV ASEDKVSIML SSGAGLEVGV QGPFLSVTVL LPEKFLTHTR GLLGTLNDNP
SDDFTLRNGQ VLPPKASAQQ VFQFGADWVV SNTSSLFTYD SWYLVYKFLI QPKHDPNFKP
LFLDEITLSP SQAEEVDRLC EGDHFCIHDV ISTGNLSVGN ATRAAHQLHR QRLKSLQPVV
SCGWLPPPSN GHKEGSKYLV DSIVRFSCNS GYSLVGSETS ICRADGTWSM STPECQPGRS
YAVLLGIIFG GLGIVALISI VYVLLHRRRK GNM
//
