ID G3HYC9_CRIGR Unreviewed; 457 AA.
AC G3HYC9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Nuclear factor interleukin-3-regulated protein {ECO:0000256|ARBA:ARBA00018259, ECO:0000256|PIRNR:PIRNR019029};
GN ORFNames=I79_016054 {ECO:0000313|EMBL:EGW11462.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW11462.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- FUNCTION: Acts as a transcriptional regulator that recognizes and binds
CC to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many
CC cellular and viral promoters. Represses transcription from promoters
CC with activating transcription factor (ATF) sites. Represses promoter
CC activity in osteoblasts. Represses transcriptional activity of PER1.
CC Represses transcriptional activity of PER2 via the B-site on the
CC promoter. Activates transcription from the interleukin-3 promoter in T-
CC cells. Competes for the same consensus-binding site with PAR DNA-
CC binding factors (DBP, HLF and TEF). Component of the circadian clock
CC that acts as a negative regulator for the circadian expression of PER2
CC oscillation in the cell-autonomous core clock. Protects pro-B cells
CC from programmed cell death. {ECO:0000256|PIRNR:PIRNR019029}.
CC -!- SUBUNIT: Homodimer. Binds DNA as a dimer.
CC {ECO:0000256|PIRNR:PIRNR019029}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR019029}.
CC -!- SIMILARITY: Belongs to the bZIP family. NFIL3 subfamily.
CC {ECO:0000256|ARBA:ARBA00006079, ECO:0000256|PIRNR:PIRNR019029}.
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DR EMBL; JH000919; EGW11462.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HYC9; -.
DR STRING; 10029.G3HYC9; -.
DR PaxDb; 10029-XP_007627321-1; -.
DR eggNOG; KOG3119; Eukaryota.
DR InParanoid; G3HYC9; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR GO; GO:0006955; P:immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14694; bZIP_NFIL3; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR047229; NFIL3-like.
DR InterPro; IPR047106; NFIL3-like_bZIP.
DR InterPro; IPR016743; NFIL3/E4BP4.
DR InterPro; IPR010533; Vert_IL3-reg_TF.
DR PANTHER; PTHR15284; NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN; 1.
DR PANTHER; PTHR15284:SF1; NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN; 1.
DR Pfam; PF07716; bZIP_2; 1.
DR Pfam; PF06529; Vert_IL3-reg_TF; 1.
DR PIRSF; PIRSF019029; bZIP_E4BP4; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|PIRNR:PIRNR019029};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108,
KW ECO:0000256|PIRNR:PIRNR019029};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR019029};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR019029};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|PIRNR:PIRNR019029};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR019029};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR019029}.
FT DOMAIN 68..118
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 183..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 457 AA; 50460 MW; E2E4D0578BBA3CD0 CRC64;
MQTIKKEPAP LDPTSSSDKV MVLNSALAEV AEDLASGEDL LLNEGSVGKN KSSACRRKRE
FIPDEKKDAM YWEKRRKNNE AAKRSREKRR LNDLVLENKL IALGEENATL KAELLSLKLK
FGLISSTAYA QEIQKLSNST AVYFQDYQTS KATVSSFVDE HEPTMVAGSC ISVIKHSPQS
SLSDVSEVSS VEHTQESPAQ GGCRSPENKF PVIKQEPVEL ESFARESREE RGAYATSIYQ
SYMGSSFPTY SHSPPLLQVH GSTSNSPRTS EADEGVVGKS SDGEDEQQVP KGPIHSPVEL
QRVHATVVKV PEVHPSALPH KLRIKAKAMQ IKVEALDSEF EGMQKLSSPA DVIAKRHFDL
EKHSTPGMVH SSLTPFSVQV TNIQDWSLKP EHWHHKELNG KTQSSFKTGV LEVKDSGYKI
SEAESLYLKQ GMANLSAEVV SLKRFIATQP ISASDSR
//
