ID G3HZA1_CRIGR Unreviewed; 1248 AA.
AC G3HZA1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Polycystic kidney disease 2-like 1 protein {ECO:0000313|EMBL:EGW03891.1};
DE Flags: Fragment;
GN ORFNames=I79_016397 {ECO:0000313|EMBL:EGW03891.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW03891.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, cilium membrane {ECO:0000256|ARBA:ARBA00004272}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004272}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CWF19 family.
CC {ECO:0000256|ARBA:ARBA00006795}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
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DR EMBL; JH000965; EGW03891.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HZA1; -.
DR STRING; 10029.G3HZA1; -.
DR PaxDb; 10029-XP_007618050-1; -.
DR eggNOG; KOG3599; Eukaryota.
DR InParanoid; G3HZA1; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd07380; MPP_CWF19_N; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR006768; Cwf19-like_C_dom-1.
DR InterPro; IPR006767; Cwf19-like_C_dom-2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036265; HIT-like_sf.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10877:SF194; POLYCYSTIC KIDNEY DISEASE 2-LIKE 1 PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF04677; CwfJ_C_1; 1.
DR Pfam; PF04676; CwfJ_C_2; 1.
DR Pfam; PF18109; Fer4_24; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR603915-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|PIRSR:PIRSR603915-1};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|PIRSR:PIRSR603915-1};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|PIRSR:PIRSR603915-
KW 1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|PIRSR:PIRSR603915-1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR603915-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 104..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 630..665
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1009..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 618..679
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1009..1025
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 643
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-1"
FT BINDING 645
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-1"
FT BINDING 654
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-1"
FT DISULFID 207..220
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EGW03891.1"
SQ SEQUENCE 1248 AA; 141790 MW; 3C3B41F959AA2EFC CRC64;
VNIMECLKGQ ELQTLGSGAW DNPAYSSPPS PNGTLKICTV SSGTLPQPQP KKPEDKCQEK
TQRTLMSSCC LHICHSIRGL WGTTLTENIA ENRELYVKTT LRELVVYIVF LVDICLLTYG
MTSSSAYYYT KVMSELFLHT PSDSGVSFRT ISSMADFWDG PLLDSLYWTK WYNNQSLGRG
SHSFIYYENL LLGVPRLRQL RVRNDSCVVH EDFREDILNC YDVYSPDKED QLPFGPLNGT
AWTYHSQNEL GGSSHWGRLT SYSGGGYYLD LPGSRQASAE VLRGLQEGLW LDRGTRVVFI
DFSVYNANIN LFCILRLVVE FPATGGTIPS WQIRTVKLIR YVSNWDFFIV GCEVIFCVFI
FYYVVEEILE IHLHRFHYLS SIWNILDLLI ILLSIVAVGF HIFRTLEVNR LMGKLLQQPD
TYADFEFLAF WQTQYNNMNA VNVFFAWIKI FKYISFNKTM TQLSSTLARC AKDILGFAVM
FFIVFFAYAQ LGYLIFGTQV ENFSTFVKCI FTQFRIILGD FDYNAIDNAN RILGPVYFVT
YVFFVFFVLL NMFLAIINDT YSEVKEELAN QKDELQLSDL LKQSYKKTLL KLRLRKERVS
DVQKVLKGGE PEIQFEDFTN TLRELGHAEN EISELKAAFT RFDQDGNRVL DEKEQAQMRQ
GLEEERVALS AEIENLGQSF GYSPRGELGT EAAKGGGWVS GEEFYTLTRR VLQLEHVLEG
VVSKVDAMGS KLKMPESKED LAPSPGMLLL CVGNFFGSTQ DAEWEEYKTG KKKAPIQTYV
LGANNPETVQ YFQDTDGCEL AENITYLGRK GFFTGSSGLQ IVYLSGTESL SEPVPSHSFS
PKDVSSLRTM LCSASQFKGV DILLTSPWPK YVGNFGNSSG EVDTKKCGSA LISSLAASLK
PRYHFAALEK SYYERLPYRN HVVLQESTQH ATRFIALANV GNAEKKKYLY AFSIVPMKLM
AAAELVKQPP DVTENPYRES GKAAAIGKHV PAPQEEPACQ FFFDLNEKQG RKRSSTGRDS
KSPQAKQPRR PPQPPGPCWF CLASPEVEKH LVVNIGTHCY LALAKGGLSD DHVLILPIGH
YQSVVELSAE VVEEVEKYKA TLKRFFKSRG KRCVLFERNY RSHHLQLQVI PVPLSCCVTD
DIKDAFITQA QEQQIELLEI PEHSDIKQIA QPGAAYFYVE LDTGEKLFHR IKKNFPLQFG
REVLASEAIL NIPDKADWRQ CQISKEEEET LARRFRKDFE PFDFTLDD
//
