ID G3HZL3_CRIGR Unreviewed; 1182 AA.
AC G3HZL3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=FH1/FH2 domain-containing protein 1 {ECO:0000313|EMBL:EGV97035.1};
GN ORFNames=I79_016520 {ECO:0000313|EMBL:EGV97035.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV97035.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
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DR EMBL; JH000973; EGV97035.1; -; Genomic_DNA.
DR RefSeq; XP_003508593.1; XM_003508545.3.
DR AlphaFoldDB; G3HZL3; -.
DR STRING; 10029.G3HZL3; -.
DR PaxDb; 10029-XP_007610022-1; -.
DR GeneID; 100760903; -.
DR CTD; 29109; -.
DR eggNOG; KOG1925; Eukaryota.
DR InParanoid; G3HZL3; -.
DR OMA; VRVMQFC; -.
DR OrthoDB; 2918313at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR041387; FHOD1_GBD_N.
DR InterPro; IPR014768; GBD/FH3_dom.
DR PANTHER; PTHR45920:SF2; FH1_FH2 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45920; FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I; 1.
DR Pfam; PF02181; FH2; 1.
DR Pfam; PF18382; Formin_GBD_N; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 53..409
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 633..1030
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 345..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..626
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1182 AA; 128540 MW; C1BD98FAED36AFC3 CRC64;
MAGEEDRGDG DPVSVVTVRV QYLEDTDPFA CANFPEPRRA PTCSLDGGLP LSAQIPALHR
LLGAPLKLED CALQVSPSGY YLDPELSLEE QREMLEGFYE EISKGRKPTL ILRTQLSVRV
NAILEKLYGS SGPELRRSLF SLKQIFQEDK DLVPEFVHSE GLSCLIRVGA AADHNYQSYI
LRALGQLMLF VDGMLGVVAH SETVQWLYTL CASLSRLVVK TALKLLLVFV EYSENNAPLF
IQAVNSVAST TGTLPWANLV SILEEKNGAD PELLVYTVTL INKTLAALPD QDSFYDVTDA
LEQQGMEALV QRLLGTSGTD VDLRTQLMLY ESALRFEDGD MEEAAAAAAA GGRRERRKPS
SEEGKRSRRS LEGGGCPVRT PEPGSTGPAS PVGSTSFPGP TLLTSPGISP TGPASGLRTS
VNLFPTISVG PSVDSSCERS IYKARFLENV AAAETEKQAA LAQGRAETLA GATVDETDGS
SPSGTRELWD SPEPASAPRT PQSPVSRILL RTQQSLEPEP KEPVLPPSPK AEPVHELPTR
VPKLCIGDLD FSDLGEDEDQ DTLNMASVES EKTFPLLPHP PSSLSGGSPP PPPPPPPILG
SLPPPPPPPP PPILGSCPPP PPLAAPFSRS ALDGPTLPTK RKTVKLFWRE LKLAGGPGFS
GNRFGPCPTL WASLEPVSVD TARLEHLFES RAKDVLPTKK AGEGRRTMTT VLDPKRSNAI
NIGLTTLPPV HVIKAALLNF DEFAVSKDGI EKLLTMMPTE EERQKIEEAQ LANPDVPLGP
AENFLMTLAS IGGLAARLQL WAFKLDYDSM EREIAEPLFD LKVGMEQLVH NATFRCILAT
LLAVGNFLNG SKSSGFELSY LEKVSEVKDT VRRQSLLYHL CSLVLQTRPD SSDLYSEIPA
LTRCAKVDFE QLTENLGQLE CRSQAAEDSL RSLAKHELAP ALRARLTHFL AQCTRRVAML
RVVHRRVCNR FHAFLLYLGY TAQAAREVRI MQFCHTLREF ALEYRTCRER VLQQQQKRAT
YRERNKTRGR MITETEKFSG VAGEAPSNLS VPVAVSSGPG QGDADSHATM KSLLTSRPED
TVHSRRSRGM VQSSSPVTHT AVGASTVSPE ETSASSLPSD TSDEIMDLLV QSVTKSSPRA
LAARERKRSR GNRKSLRRTL KSGLGDDLVQ ALGLSKAPGL EV
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