ID G3I1C7_CRIGR Unreviewed; 286 AA.
AC G3I1C7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Calcium-activated potassium channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE Short=BKbeta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=BK channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Charybdotoxin receptor subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=K(VCA)beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Maxi K channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Slo-beta {ECO:0000256|RuleBase:RU368097};
GN ORFNames=I79_017180 {ECO:0000313|EMBL:EGW10763.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW10763.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1
CC (maxiK) channel. Modulates the calcium sensitivity and gating kinetics
CC of KCNMA1, thereby contributing to KCNMA1 channel diversity.
CC {ECO:0000256|RuleBase:RU368097}.
CC -!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules
CC of KCMNB per KCNMA1 tetramer. {ECO:0000256|RuleBase:RU368097}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU368097}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU368097}.
CC -!- PTM: N-glycosylated. {ECO:0000256|RuleBase:RU368097}.
CC -!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family.
CC {ECO:0000256|RuleBase:RU368097}.
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DR EMBL; JH001066; EGW10763.1; -; Genomic_DNA.
DR AlphaFoldDB; G3I1C7; -.
DR STRING; 10029.G3I1C7; -.
DR PaxDb; 10029-XP_007607101-1; -.
DR eggNOG; ENOG502QR4Z; Eukaryota.
DR InParanoid; G3I1C7; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0015269; F:calcium-activated potassium channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005513; P:detection of calcium ion; IEA:UniProtKB-UniRule.
DR InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
DR PANTHER; PTHR10258; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA; 1.
DR PANTHER; PTHR10258:SF4; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-3; 1.
DR Pfam; PF03185; CaKB; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|RuleBase:RU368097};
KW Ion channel {ECO:0000256|RuleBase:RU368097, ECO:0000313|EMBL:EGW10763.1};
KW Ion transport {ECO:0000256|RuleBase:RU368097};
KW Membrane {ECO:0000256|RuleBase:RU368097};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transmembrane {ECO:0000256|RuleBase:RU368097};
KW Transmembrane helix {ECO:0000256|RuleBase:RU368097};
KW Transport {ECO:0000256|RuleBase:RU368097}.
FT TRANSMEM 51..74
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368097"
FT TRANSMEM 199..221
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368097"
FT REGION 21..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 286 AA; 31792 MW; FF1DDEF42D991C3A CRC64;
MANDCTLSCS HSILFGPPPH QRTALPASGK SNGDLPRVHP KLPSSAGEDR AMLLGVAMMA
SSVLMLFLLG ITVLKPFMLS SNREESNCTT VHTHIADDWL DFAFTCEGSC QDHSRYPCLQ
VFVNLTHSGQ KVLLHYDDEA VRANPKCFYT PKCYGDKDDL LNSARDIKKF FDHRNGTFTC
FYSPDGQLGV VLRKSGYKVV FHCLFWPLLT LLGGALIVGL VRLTQHLSLR CEQYSTVVRV
QAGGKTQWSA GSHRSSMCSV AKSQGRDREL KRQPLLSRSE ILQLKI
//
