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Database: UniProt
Entry: G3I1T3_CRIGR
LinkDB: G3I1T3_CRIGR
Original site: G3I1T3_CRIGR 
ID   G3I1T3_CRIGR            Unreviewed;      2352 AA.
AC   G3I1T3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   31-JUL-2019, entry version 45.
DE   SubName: Full=ATP-binding cassette transporter sub-family C member 8 {ECO:0000313|EMBL:EGW12081.1};
DE   Flags: Fragment;
GN   ORFNames=I79_017352 {ECO:0000313|EMBL:EGW12081.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW12081.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- INTERACTION:
CC       Q61743:Kcnj11 (xeno); NbExp=3; IntAct=EBI-10953250, EBI-8603527;
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DR   EMBL; JH001091; EGW12081.1; -; Genomic_DNA.
DR   IntAct; G3I1T3; 1.
DR   STRING; 10029.XP_007636846.1; -.
DR   PRIDE; G3I1T3; -.
DR   InParanoid; G3I1T3; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015272; F:ATP-activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008281; F:sulfonylurea receptor activity; IEA:InterPro.
DR   Gene3D; 1.20.1560.10; -; 2.
DR   Gene3D; 2.60.40.1400; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR000844; ABCC8.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR003279; K_chnl_inward-rec_Kir6.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR24223:SF187; PTHR24223:SF187; 2.
DR   Pfam; PF00664; ABC_membrane; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 2.
DR   Pfam; PF00595; PDZ; 2.
DR   Pfam; PF17820; PDZ_6; 1.
DR   PRINTS; PR01332; KIR62CHANNEL.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM00228; PDZ; 3.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   SUPFAM; SSF90123; SSF90123; 2.
DR   PROSITE; PS50929; ABC_TM1F; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR   PROSITE; PS50106; PDZ; 3.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00434,
KW   ECO:0000313|EMBL:EGW12081.1}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00434};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    717    736       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    748    766       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    778    797       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    999   1023       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1029   1047       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1105   1128       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1140   1162       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1603   1626       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1700   1722       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1798   1816       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1822   1841       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2140   2161       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       75    143       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      204    274       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      595    668       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      963   1171       ABC transmembrane type-1.
FT                                {ECO:0000259|PROSITE:PS50929}.
FT   DOMAIN     1223   1470       ABC transporter. {ECO:0000259|PROSITE:
FT                                PS50893}.
FT   DOMAIN     1555   1850       ABC transmembrane type-1.
FT                                {ECO:0000259|PROSITE:PS50929}.
FT   DOMAIN     1874   2096       ABC transporter. {ECO:0000259|PROSITE:
FT                                PS50893}.
FT   NP_BIND    1264   1271       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00434}.
FT   NP_BIND    1917   1924       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00434}.
FT   REGION      389    439       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1482   1502       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      294    314       {ECO:0000256|SAM:Coils}.
FT   COILED      316    370       {ECO:0000256|SAM:Coils}.
FT   COILED     1503   1523       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    391    439       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:EGW12081.1}.
SQ   SEQUENCE   2352 AA;  264365 MW;  BB39A31A0C98968B CRC64;
     VDFLIENDAE KDYLYDVLRM YHQTMDVAVL VGDLKLVINE PNRLPLFDAI RPLIPLKHQV
     EYDQLTPRRS RKLKEVRLDR LHPEGLGLSV RGGLEFGCGL FISHLIKGGQ ADSVGLQVGD
     EIVRINGYSI SSCTHEEVIN LIRTKKTVSF PNLLCFPTDI GLIPVKSSPE EPLKWQYVDQ
     FVSESGGVRG GLGSPGNRTT KEKKVFISLV GSRGLGCSVS SGPIQKPGIF ISHVKPGSLS
     AEVGLETGDQ IVEVNGIDFS NLDHKEAVNV LKSSRSLTIS IVAGAGRELF MTDRERLEEA
     RQRELQRQEL LMQKRLAMES NKILQEQQEM ERQRRKEIAQ KAAEENERYR KEMEEIMEEE
     EKFKKQWEED WGSKEQLILP KTITAEVHPT PLRKPKYDQG VEAKLEPADH LDGNTEKRGP
     QKGAEKKKAK HDSLQDLRKN KKELEFEQKL YKEKEEMLEK EKQLKINRLA QEVSETERED
     LEESEKTQYW VERLCQTRLQ QISSAENEIA ETFCPSPKPP RGPGVSTISK PVMVHQEPNF
     IYRPAVKSEV LLVFVMCLSG FYILKPFLCF QDFRKYEEGF DPYSMFSPEQ IAGKDVRLLR
     IKKEGSLDLA LEGGVDSPVG KVVVSAVYEG GAAERHGGVV KGDEIMAING KIVTDYTLAE
     AEAALQKAWN QGGDLLLKSG ERAQPDSILE SRWGRQRSQV HIHHSTWLHF PGHNLRWILT
     FILLFVLVCE IAEGILSDGV TESRHLHLYM PAGMAFLAAV TSVVYYHNIE TSNFPKLLIA
     LLIYWTLAFI TKTIKFVKFY DHAIGFSQLR FCLTGLLRYI FFKTPREVKP PEDLQDLGVR
     FLQPFVNLLS KGTYWWMNAF IKTAHKKPID LRAIGKLPIA MRALTNYQRL CEAFDAQARK
     DMQSPQGARA IWRALCHAFG RRLILSSTFR ILADLLGFAG PLCIFGIVDH LGKEHHVFQP
     KTKIYNKIMH LSTSNLSMGE MTAGQICNLV AIDTNQLMWF FFLCPNLWAM PVQIIVGVIL
     LYYILGVSAL IGAAVIILLA PVQYFVATKL SQAQRSTLEY SNERLKQTNE MLRGIKLLKL
     YAWENIFCSR VEMTRRKEMT SLRAFAVYTS ISIFMNTAIP IAAVLITFVG HVSFFKESDF
     SPSVAFASLS LFHILVTPLF LLSSVVRSTV KALVSVQKLS EFLSSAEIRE EQCAPREPAP
     QGQASKYQAV PLKVVNRKRP AREEVQDLLG PLQRLAPSMD GDADNFCVQL LPSIATGQLT
     MIVGQVGCGK SSLLLATLGE MQKVSGAVFW NSIPERETAA GSDIRSRGPV AYASQKPWLL
     NATVEENITF ESPFNKQRYK KVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV
     ARALYQHTNV VFLDDPFSAL DVHLSDHLMQ APILELLRDD KRTVVLVTHK LQYLPHADWI
     IAMKDGTIQR EGTLKDFQRS ECQLFEHWKT LMNRQDQELE KETVMERKAS EPSQGLPRAM
     SSRDGLLLDE EEEEEEAAES EEDDNLSSVL HQRAKIPWKA CTKYLSSAGI LLLSLLVFSQ
     LLKHMVLVAI DYWLAKWTDS VLVLSPAARN CSLSQECALD QSVYAMVFTV LCSLGIVLCL
     VTSVTVEWTG LKVAKRLHRS LLNRIILAPM RLEAGGVSVC RSALIQEAGR IDIYSTDPHI
     PSTLECLSRS TLLCVSALTV ISYVTPVFLV ALLPLAVVCY FIQKYFRVAS RDLQQLDDTT
     QLPLLSHFAE TVEGLTTIRA FRYEARFQQK LLEYTDSNNI ASLFLTAANR WLEVRMEYIG
     ACVVLIAAAT SISNSLHGEL SAGLVGLGLT YALMVSNYLN WMVRNLADME IQLGAVKRIH
     ALLKTEAENY EGLLGHSAVT SHTCAHPRSQ CCDLPHLCTP QGHSVPLLLC FQIGICGRTG
     SGKSSFSLAF FRMVDMFEGR IIIDGIDIAK LPLHTLRSRL SIILQDPVLF SGTIRFNLDP
     EKKCSYSTLW EALEIAQLKL VVKALPGGLD AIITEGGENF SQGQRQLFCL ARAFVRKTSI
     FIMDEATASI DMATHRVHTI LSADLVMVLK RGAILEFDKP ETLLSQKDSV FASFVRADKR
     ARFVSKKGNC NVAHKNIREQ GRFLQDVFTT LVDLKWPHTL LIFTMSFLCS WLLFAMVWWL
     LPFSHGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIT LRHGRLCFML RVGDLRKSMI
     ISATIHMQVV PLAPSDLHHH QDLEIIVILE GVVETTGITT QARTSYLADE KPWGQRFVPI
     VAEEDGRYSV DYSKFGNTVK VPTPLCTARQ LDEDRSLLDA LTLASTRGPL RKRSVAVAKA
     KPKFSISPDS LS
//
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