ID G3I257_CRIGR Unreviewed; 470 AA.
AC G3I257;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Ubiquitin-conjugating enzyme E2 variant 3 {ECO:0000313|EMBL:EGW00384.1, ECO:0000313|RefSeq:XP_027266275.1};
GN Name=Uevld {ECO:0000313|RefSeq:XP_027266275.1};
GN ORFNames=I79_017482 {ECO:0000313|EMBL:EGW00384.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW00384.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW00384.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_027266275.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027266275.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027266275.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH001111; EGW00384.1; -; Genomic_DNA.
DR RefSeq; XP_003509392.1; XM_003509344.3.
DR RefSeq; XP_027266275.1; XM_027410474.2.
DR STRING; 10029.G3I257; -.
DR PaxDb; 10029-XP_007625692-1; -.
DR GeneID; 100751959; -.
DR KEGG; cge:100751959; -.
DR CTD; 55293; -.
DR eggNOG; KOG1495; Eukaryota.
DR eggNOG; KOG2391; Eukaryota.
DR InParanoid; G3I257; -.
DR OMA; CIMGANG; -.
DR OrthoDB; 5344346at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP001108280; Chromosome 3.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR001557; L-lactate/malate_DH.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR PANTHER; PTHR43128:SF32; UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 3; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR Pfam; PF05743; UEV; 1.
DR PRINTS; PR00086; LLDHDRGNASE.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51322; UEV; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 2..145
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
SQ SEQUENCE 470 AA; 52053 MW; ED6408B21467E613 CRC64;
MEFDCEGVRR LLGKYKFRDL TVEELKNVNM YFPHFRYSMD TYVFKDTSQK DLLNFTGTIP
VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMEISVG KHVDAKGRIY LPYLQNWSHP
KSVIVGLIKE MIAKFQEELP LYSVPSSNEA QQVDLLAYIA KITEGVSDIN SRGWTNHENK
IPNKITVVGS GDLGIACTLA ISAKGIADKL LLLDLSDGTN QGTMDLDIFN LPNVEISKDL
SASAHSKVVI FTANSLGGFE SYLHAVQSNV DMFRTLVPAL GHYNQHAVFL VASQPVEIMS
YVTWKLSTFP ANRVIGIGCN LDSQRLQYII MNVLKAQTSG KKVWVVGEQG ENKVCSWSGP
DGVMSHSSQA ELSSRAMELL RVKGQRSWSV GLSVADLVDT IVNNKKKVHS VSTLAKGYYG
LDNEVFLSLP CILGTSGVSE VKTTAGEDPM TETLQNSGSS IHNLQQQLKL
//
