ID G3I5T6_CRIGR Unreviewed; 607 AA.
AC G3I5T6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN ORFNames=I79_018843 {ECO:0000313|EMBL:EGW03550.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW03550.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH001320; EGW03550.1; -; Genomic_DNA.
DR AlphaFoldDB; G3I5T6; -.
DR STRING; 10029.G3I5T6; -.
DR InParanoid; G3I5T6; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.60.21.10; -; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR013235; PPP_dom.
DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR45668; SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED; 1.
DR PANTHER; PTHR45668:SF5; SERINE_THREONINE-PROTEIN PHOSPHATASE 5; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF08321; PPP5; 1.
DR SMART; SM00156; PP2Ac; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 430..602
FT /note="Serine/threonine specific protein phosphatases"
FT /evidence="ECO:0000259|SMART:SM00156"
FT REGION 50..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 67498 MW; 7A0ABE15D181DE1F CRC64;
MALCSVHPAD PPVPRILAFL HPPALSEASL AADPRRFCSP DLRRLMAPIL DGPPIAATPS
TPQATRRPQS PLPADLPDQL LRGLENAYRL STARKNKTVE TDLDKTQDPD TLDLEMLAPY
ISMDDDFQLN SSEQLPRTHR RPPRVARRPR ARSFHGLSPP IPEPSLLPRW GSDPRLNCSS
PSTGDPPTAS LMPGTRKRAL AQSSEDKGAE LLETKPASLE PASFRLPPLS LSFLLQGRQF
PGNQQDPRSQ LLDSHEPLAK DYENAIKYYS QAIDLNPNNA IYYGNRSLAY LRTECYGYAL
GDATRAIELD KKYIKGYYRR AASNMALGKP KQLYSSTNKS NTYPQHTVVK VKPNDKDAKM
KYQECSKIVK QKAFERAIAG DEHRRSVVDS LDIESMTIED EYSGPKLEDG KVTITFMKEL
MQWYREQKKL HRKCAYQILV QVKEVLCKLS TLVETTLEET EKITVCGDTH GQFYDLLNIF
ELNGLPSETN PYVSSRVAPC GEGGAPLGKN TGTDRHLTVT VVTAPPGYKN GRSVSKRGVS
CQFGPDVTKA FLEENQLEYI IRSHEVKAEG YEVAHGGRCV TVFSAPNYWC VSPSHPLLGA
QGLLCGF
//
