ID G3I5Z8_CRIGR Unreviewed; 1839 AA.
AC G3I5Z8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Ecm29 proteasome adaptor and scaffold {ECO:0000313|Ensembl:ENSCGRP00001022480.1};
DE SubName: Full=Proteasome adapter and scaffold protein ECM29 isoform X1 {ECO:0000313|RefSeq:XP_027258820.1, ECO:0000313|RefSeq:XP_027258821.1};
DE SubName: Full=Proteasome-associated protein ECM29-like {ECO:0000313|EMBL:EGW11193.1};
GN Name=Ecpas {ECO:0000313|Ensembl:ENSCGRP00001022480.1,
GN ECO:0000313|RefSeq:XP_027258820.1, ECO:0000313|RefSeq:XP_027258821.1};
GN ORFNames=I79_018909 {ECO:0000313|EMBL:EGW11193.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW11193.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW11193.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001022480.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027258820.1, ECO:0000313|RefSeq:XP_027258821.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027258820.1,
RC ECO:0000313|RefSeq:XP_027258821.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027258820.1,
RC ECO:0000313|RefSeq:XP_027258821.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH001327; EGW11193.1; -; Genomic_DNA.
DR RefSeq; XP_003510625.1; XM_003510577.3.
DR RefSeq; XP_007616608.1; XM_007618418.2.
DR RefSeq; XP_027258820.1; XM_027403019.2.
DR RefSeq; XP_027258821.1; XM_027403020.2.
DR STRING; 10029.G3I5Z8; -.
DR PaxDb; 10029-XP_007616609-1; -.
DR Ensembl; ENSCGRT00001026725.1; ENSCGRP00001022480.1; ENSCGRG00001020995.1.
DR GeneID; 100757449; -.
DR CTD; 23392; -.
DR eggNOG; KOG0915; Eukaryota.
DR GeneTree; ENSGT00940000153612; -.
DR OMA; CRIKDIE; -.
DR OrthoDB; 1060702at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0043248; P:proteasome assembly; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024372; Ecm29.
DR PANTHER; PTHR23346:SF19; PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29; 1.
DR PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR Pfam; PF13001; Ecm29; 1.
DR Pfam; PF12755; Vac14_Fab1_bd; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Proteasome {ECO:0000313|EMBL:EGW11193.1,
KW ECO:0000313|RefSeq:XP_027258820.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 187..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1839 AA; 203792 MW; 612F704FB66F22CF CRC64;
MYHIDCRDQL ERVFLRLGHA ETDEQLQNII SKFLPPVLLK LSSTQEGVRK KVMELLVHLN
KRIKSRPKIQ LPVETLLVQY QDPAAVSFVT NFTIIYVKMG YPRLPVEKQC ELAPTLLTAM
EGKPQPQQDS LMHLLIPTLF HMKYPAESSK SASPFNLAEK PKTVQLLLDF MLDVLLMPYG
YVLNESQSRQ NSSSSQGSSS NSGGGSGIPQ PPPGMSFYAA KRVIGDNPWT PEQLEQCKLG
IVKFIEAEQV PELEAVLHLV IASSDTRHSV ATAADLELKS KQSLIDWNNP AIINKMYKVY
LGDIPLKTKE GAVLKPELKR DPVSTRVKLK IVPHLLRSRQ AAETFPANIQ VVYDGLFGTN
TNSKLRTLSL QFVHHICITC PEIKIKPLGP MLLNGLTKLI NEYKEDPKLL SMAYSAVGKL
SSRMPHLFTK DIALVQQLFE ALCKEEPETR LAIQEALSMM VGAYSTLEGA QRTLMEALVA
SYLIKPEVQV RQVAVKFAST VFPSDHIPSR YLLLLAAGDP REEVHGEAQR VLRCLPGRNK
KESASKQMPS FPEMVYYIQE KASHRMKTPV KYMTGTTVLP FNPAAFGEII LYLRMCLAHS
AGVVPTSQSL ADMQDHAPAI GRYIRTLMSS SQATASSSNK SGETNPVQIY IGLLQQLLAG
VGGLPVMYCL LEAVSVYPEK LATKFVDKTE WIKSLMSSSK EEMRELAALF YSVVVSTVSG
NELKSMIEQL IKSTKDNHSP EVQHGSLLAL GFTVGRYLAK KKMRMAEQQD LETDADLLPE
QEDLIRSATE IIGSFLDSTS PLLAIAACTA LGEIGRNGPL PIPSEGSGFT KLHLVESLLN
RIPSSKETNK MKERAIQTLG YFPVGDGGFP HQKLLLRGLM DSVEAKQIEL QFTIGEAITS
AAIGTNSVAA RDAWLVTEEE YTPLAGAKMN DVVPWVLEVI LSKHIISPNP HVRQAACIWL
LSLVRKLSTH IEVKSHLKEI QSAFISVLSE NDELSQDVAS KGLGLVYELG SEQDQQELVS
TLVETLMTGK RAKHEVSGET VVFQGGGLGK TPDGQGLSTY KELCSLASDL SQPDLVYKFM
NLANHHAMWN SRKGAAFGFN VIATRAGEQL APFLPQLIPR LYRYQFDPNL GIRQAMTSIW
NALVTDKSMV DKYLKEILQD VIKNLTSNMW RVRESSCLAL NDLLRGRPLD DVIDKLPEMW
ETLFRVQDDI KESVRKTAEL VLKTLSKVCV KMCDPAKGAA GQRTIAVLLP CLLDKGMMSP
VTEVRALSIN TLVKISKSAG AMLKPHAPKL IPALLESLSV LEPQVLNYLS LRATEQEKAA
MDSARLSAAK SSPMMETINM CLQYLDVSVL GELVPRLCEL IRSGVGLGTK GGCASVIVSL
TTQCPQDLTP YSGKLMSALL SGLTDRNSVI QKSCAFAMGH LVRTSRDSST EKLLQKLNGW
YMEKEEPIYK TACALTIHAI GRYSPDVLKN HAKEVLPLAF LGMHEIADEE KPEKEECNLW
TEVWQENVPG SFGGIRLYLQ ELIAITQKAL QSQSWKMKAQ GAIAMASIAK QTSSLVPPYL
GMILSALVQG LAGRTWAGKE ELLKAIACVV TACSTELEKS VPNQPTTNEI LQAVLKECCK
ENLKYKIVAI SCAADVLKAT KEDRFQEFSD IVIPLIKKNS LESMGVRSTK AEDENDKERE
LQLESLLGAF ESLGKAWPRN PETQRCYRQE LCKLMCERLR LSTWKVQLGV LQSMNAFFQG
LMLLEEEHAD SEALAEILLE TCKSITYSLE NKTYSSVRTE ALSVVELLLK KLEEAKQWES
LTAECRRLLV ESLATMETDN RPELQEKASV LKKTLESLE
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