ID G3I911_CRIGR Unreviewed; 1537 AA.
AC G3I911;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Brain-specific angiogenesis inhibitor 1 {ECO:0000313|EMBL:EGV97375.1};
GN ORFNames=I79_020044 {ECO:0000313|EMBL:EGV97375.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV97375.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JH001556; EGV97375.1; -; Genomic_DNA.
DR STRING; 10029.G3I911; -.
DR InParanoid; G3I911; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR CDD; cd15251; 7tmB2_BAI_Adhesion_VII; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR12011:SF39; ADHESION G PROTEIN-COUPLED RECEPTOR B1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 4.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1537
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003444924"
FT TRANSMEM 937..958
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 970..989
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1001..1019
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1040..1059
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1079..1102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1123..1145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 510..580
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 935..1176
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 314..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1373..1454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1485..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1378..1416
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1437..1451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1537 AA; 167930 MW; 8A4F9938F49BBA06 CRC64;
MRGQAAAPGP IWILAPLLLL LLLLGRRARA ASGADIGPGA EQCTTLVQGK FFGYFSAAAV
FPANASRCSW TLRNPDPRRY TLYMKVAKAP APCSSPGRVR TYQFDSFLES TRTYLGVESF
DEVLQLCDPS APLAFLQASK QFLQMQRQQP PQDGDLGPRS TFPNSGDDFS VEYLVVGNRN
PSHAACQMLC RWLDACLAGS RSSHPCGIMQ TPCACLGGDA GDPASSPLVP RGDVCLRDGV
AGGPENCLTS LTQDRGRHGS AGGWKLWSLW GECTRDCGGG LQTRTRTCLP TPGVEGGGCE
GVLEEGRLCN RKACGPTGRT SSRSQSLRST DARRREELGD ELQQFGFPSP QTGDPAAEEW
SPWSVCSSTC GEGWQTRTRF CVSSSYSTQC SGPLREQRLC NNSAVCPVHG AWDEWSPWSL
CSSTCGRGFR DRTRTCRPPQ FGGNPCEGPE KQTKFCNIAL CPVDGKWQAW ASLGSCSVTC
GGGSQRRERV CSGPFFGGAA CQGPQDEYRQ CGAQRCPEPH EICDEDNFGA TVWKETPAGE
VAAVRCPRNA TGLILRRCEL DEEGIAYWEP PTYIRCVSID YRNIQMMTRE HLAKAQRGLP
GEGVSEVIQT LLEISQDGTS YSGDLLSTID VLRNMTEIFR RAYYSPTPGD VQNFVQIISN
LLAEENRDKW EEAQLMGPNA KELFRLVEDF VDVIGFRMKD LRDAYQVTDN LVLSIHKLPA
SGATDISFPM KGWRATGDWA KVPEDRVTVS KSVFSTGLAE ADDSSVFVVG TVLYRNLGSF
LALQRNTTVL NSKVISVTVK PPPRSLLTPL EIEFAHMYNG TTNQTCILWD ETDGLGLESL
ALVILSWVRR QPFLPCPWKA KLIDTTAEVL DSIGSQAGGF PGGDQQLSAW RPVDPAWASG
KLPGCQNSSP LFLRVLSPEA FPATNRQNMD KATVPSVTLI VGCGVSSLTL LMLVIIYVSV
WRYIRSERSV ILINFCLSII SSNALILIGQ TQTRNKVVCT LVAAFLHFFF LSSFCWVLTE
AWQSYMAVTG RLRSRLVRKR FLCLGWGLPA LVVAISVGFT KAKGYSTMNY CWLSLEGGLL
YAFVGPAAAV VLVNMVIGIL VFNKLVSKDG ITDKKLKERA GASLWSSCVV LPLLALTWMS
AVLAVTDRRS ALFQILFAVF DSLEGFVIVM VHCILRREVQ DAVKCRVVDR QEEGNGDSGG
SFQNGHAQLM TDFEKDVDLA CRSVLNKDIT ACRTATITGT FKRPSLPEEE KLKLAKGPPP
TFNSLPANVS KLHLHGSPRY PGGPLPDFPN HSLTLKKDKA PKSSFIGDGD IFKKLDSELS
RAQEKALDTS YVILPPATAT LRPKPKEEPK HSINIDQMPQ TRLIHLSVAL DASFPTRNPP
AREPPGGGPP EAPPAQPPPP PPQQPLPPPP TLEPAPPSLG DTGEPAAHPG PSPGAGTKNE
NVATLSVSSL ERRKSRYAEL DFEKIMHTRK RHQDMFQDLN RKLQHAAEKE KEVPGVDSKE
LEPLPPSPLE LRSVEWEKAG ATIPLVGQDI IDLQTEV
//
