ID G3I956_CRIGR Unreviewed; 772 AA.
AC G3I956;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=DnaJ homolog subfamily C member 16 {ECO:0000256|ARBA:ARBA00020921};
DE AltName: Full=Endoplasmic reticulum DNA J domain-containing protein 8 {ECO:0000256|ARBA:ARBA00035043};
GN Name=Dnajc16 {ECO:0000313|Ensembl:ENSCGRP00001020142.1,
GN ECO:0000313|RefSeq:XP_027255746.1, ECO:0000313|RefSeq:XP_027255747.1};
GN ORFNames=I79_020090 {ECO:0000313|EMBL:EGV96885.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV96885.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV96885.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001020142.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027255746.1, ECO:0000313|RefSeq:XP_027255747.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027255746.1,
RC ECO:0000313|RefSeq:XP_027255747.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027255746.1,
RC ECO:0000313|RefSeq:XP_027255747.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays an important role in regulating the size of
CC autophagosomes during the formation process.
CC {ECO:0000256|ARBA:ARBA00035002}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004163}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
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DR EMBL; JH001574; EGV96885.1; -; Genomic_DNA.
DR RefSeq; XP_003511589.1; XM_003511541.3.
DR RefSeq; XP_007626057.1; XM_007627867.2.
DR RefSeq; XP_007626058.1; XM_007627868.2.
DR RefSeq; XP_007650292.1; XM_007652102.2.
DR RefSeq; XP_027255746.1; XM_027399945.2.
DR RefSeq; XP_027255747.1; XM_027399946.1.
DR STRING; 10029.G3I956; -.
DR PaxDb; 10029-XP_007626057-1; -.
DR Ensembl; ENSCGRT00001024386.1; ENSCGRP00001020142.1; ENSCGRG00001019382.1.
DR GeneID; 100751780; -.
DR KEGG; cge:100751780; -.
DR CTD; 23341; -.
DR eggNOG; KOG0715; Eukaryota.
DR GeneTree; ENSGT00940000155851; -.
DR OMA; FAHIYND; -.
DR OrthoDB; 125937at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 2.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016243; P:regulation of autophagosome size; IEA:Ensembl.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd02963; TRX_DnaJ; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR043361; DNAJC16_TRX.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR44303; DNAJ HOMOLOG SUBFAMILY C MEMBER 16; 1.
DR PANTHER; PTHR44303:SF2; DNAJ HOMOLOG SUBFAMILY C MEMBER 16; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..772
FT /note="DnaJ homolog subfamily C member 16"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041117348"
FT DOMAIN 29..93
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT DOMAIN 122..245
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 560..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 88963 MW; 1F4277CD16F6668F CRC64;
MEVKKLSVSW QFWIVLFLTL QGLSALDFDP YRVLGVSRTA SQADIKKAYK KLAREWHPDK
NKDPGAEDKF IQISKAYEIL SNEEKRTNYD HYGDAGENQG YPKQQREYRF RHFHDNFYFE
ESFFHFPFNS ERRDSTDEKY LLHFSHYVNE VVPDSFKKPY LIKITSDWCF SCIHIEPVWK
EVVQELEGLG VGIGVVHAGY ERRLAHHLGA HSTPSILGII NGKISFFHNA VVHENLRQFV
ESLLPGNLVE KVTNKNYVRF LSGWQQENKP HALLFGQTPA VPLLYKLTAF AYKDYMTFGY
VYMGLRGVEE MTRQYNVNVH APTMLIFKEH INKPADVIQA RGLKKQVIED FITQNKYLLA
ARLTSQRLFH ELCPVKRSHR QRKYCVVLLT AETNKLSKPF EAFLSFALAN TQDTVRFVHV
YSTRQQEFAS TLLPDVEAFQ GKSGVSILER RNTAGRVVFK TLDDPWTGSE DDKFILLGYL
DQLRKDPAFL SSEAVLPDLT DELAPVFFLR WLYSISDSLS DWWESLLHSN WREVMPLLSL
IFSALFILFG TVIVQAFSDS NEEGESQPPD KEEVPEKPGK TEPAFTKESS SKIPKKGFVE
VTELTDVTYT SNLVRLRPGH MNVVLILSNS TKTSLLQKFA LEVYTFTGSS SLHFSFLSLD
KHREWLEYLL EFAQDAAPIP NQYDKHFMER DYTGYVLALN GHKKYFCLFK PLKTVDEEAV
GSCDPDSSRG KPPCGLGPKP LKGKLSKLSL WMERLLEGSL QRFYIPSWPE LD
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