ID G3IAI9_CRIGR Unreviewed; 600 AA.
AC G3IAI9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=HMG domain-containing protein 4 {ECO:0000313|EMBL:EGW03574.1, ECO:0000313|RefSeq:XP_027266339.1};
GN Name=Hmgxb4 {ECO:0000313|RefSeq:XP_027266339.1};
GN ORFNames=I79_020612 {ECO:0000313|EMBL:EGW03574.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW03574.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW03574.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_027266339.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027266339.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027266339.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH001715; EGW03574.1; -; Genomic_DNA.
DR RefSeq; XP_003512007.1; XM_003511959.3.
DR RefSeq; XP_007628253.1; XM_007630063.2.
DR RefSeq; XP_007628255.1; XM_007630065.2.
DR RefSeq; XP_007650661.1; XM_007652471.2.
DR RefSeq; XP_027266339.1; XM_027410538.2.
DR STRING; 10029.G3IAI9; -.
DR PaxDb; 10029-XP_007628253-1; -.
DR GeneID; 100757455; -.
DR CTD; 10042; -.
DR eggNOG; ENOG502QSH9; Eukaryota.
DR InParanoid; G3IAI9; -.
DR OrthoDB; 2917084at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP001108280; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21982; HMG-box_HMGXB4; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR025228; DUF4171.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR042477; HMGXB4.
DR InterPro; IPR048016; HMGXB4_HMG-box.
DR PANTHER; PTHR46584; HMG DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46584:SF1; HMG DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF13775; DUF4171; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 406..474
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 406..474
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 49..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..344
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 65670 MW; EC209B017B6F6C0A CRC64;
MAYDDSMKKE DCFDGDHSFE DIGLAAGRSQ REKKRSYKDF LREEEEVAAQ VRSSSKKKSK
DSELFFLGTD THKKKRKHCP DDYCYGDISS LESSQKKKKK SSPQSADTAM DLLKAITSPL
AAGAKSSKKA GEKSSSSSSH LESRKEHHKK KGNGSSGELS LEDSSAHKPK KMKPLYVNTE
TLTLREPDGL KMKLILSPKE KGGSSVEEEA FQYPAQQASL KKSSKKLARD EQGALLLGQE
LQSLLKTARK KHKSSSDSHS SPGPEGCGAD ASQLPEPHSA NLDVTGLDPI LVESESSSGG
ELEAGELVID DSYREIKKKK KSKKSKKKKD KDRHKEKRHS RTKRSSGLAA GAAREHGTAR
EHSMTPSPAP SIPTVPLPAL HTDGHGEKKK KKEEKDRERE RGEKPKKKNM SAYQVFCKEY
RVTIVADHPG IDFGELSKKL AEVWKQLPEK DKLIWKQKAQ YLQHKQNKAE ATTVKRKASS
TEGSGKVRAS SVGILSPQKK SPPTTMLLPA SPAKAPETEP IDVAAHLQLL GESLSLIGHR
LQETEGMVAV SGSLSVLLDS IICALGPLAC LTTQLPELNG CPKQVLSNTL DNIAYIMPGL
//
