ID G3IAR5_CRIGR Unreviewed; 616 AA.
AC G3IAR5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Afadin- and alpha-actinin-binding protein isoform X1 {ECO:0000313|RefSeq:XP_027251719.1};
DE SubName: Full=Afadin-and alpha-actinin-binding protein {ECO:0000313|EMBL:EGW03506.1};
DE SubName: Full=SSX family member 2 interacting protein {ECO:0000313|Ensembl:ENSCGRP00001020010.1};
GN Name=Ssx2ip {ECO:0000313|Ensembl:ENSCGRP00001020010.1,
GN ECO:0000313|RefSeq:XP_027251719.1};
GN ORFNames=I79_020694 {ECO:0000313|EMBL:EGW03506.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW03506.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW03506.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001020010.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027251719.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027251719.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027251719.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriolar satellite
CC {ECO:0000256|ARBA:ARBA00004607}.
CC -!- SIMILARITY: Belongs to the ADIP family.
CC {ECO:0000256|ARBA:ARBA00009291}.
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DR EMBL; JH001743; EGW03506.1; -; Genomic_DNA.
DR RefSeq; XP_007630288.1; XM_007632098.1.
DR RefSeq; XP_007650718.1; XM_007652528.2.
DR RefSeq; XP_027251719.1; XM_027395918.2.
DR STRING; 10029.G3IAR5; -.
DR PaxDb; 10029-XP_007630288-1; -.
DR Ensembl; ENSCGRT00001024254.1; ENSCGRP00001020010.1; ENSCGRG00001019268.1.
DR GeneID; 100759551; -.
DR KEGG; cge:100759551; -.
DR CTD; 117178; -.
DR eggNOG; ENOG502QQJF; Eukaryota.
DR GeneTree; ENSGT00390000007688; -.
DR OMA; QHCKEMI; -.
DR OrthoDB; 2963617at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 1.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0031252; C:cell leading edge; IEA:Ensembl.
DR GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0007098; P:centrosome cycle; IEA:Ensembl.
DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IEA:Ensembl.
DR GO; GO:2000145; P:regulation of cell motility; IEA:Ensembl.
DR GO; GO:0035020; P:regulation of Rac protein signal transduction; IEA:Ensembl.
DR InterPro; IPR021622; Afadin/alpha-actinin-bd.
DR PANTHER; PTHR46507; AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN; 1.
DR PANTHER; PTHR46507:SF1; AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN; 1.
DR Pfam; PF11559; ADIP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT REGION 293..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 131..218
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 377..404
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 293..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 616 AA; 71222 MW; 327E9AB87CBAB89C CRC64;
MGDWMTVTDP SLCTESKNLH QYTSETKMSP SSLYSQQVLC SSIPLSKNVH SVFSAFCTEE
NIEQSISYLD QELTTFGFPS LYEESKSKET KRELNIVAVL NCMNELLVLQ RKNLLAQESV
ETQNLKLGSD MDHLQSCYAK LKEQLETSRR EMIGLQERDR QLQCKNRNLH QLLKNEKDEV
QKLQNIIASR ATQYNHDMKR KEREYNKLKE RLHQLVMNKK DKKIAMDVLN YVGRADGKRG
SWRTDKTEAR NEDEMYKLLL NDYECRQKQI LTENAELKKV LQQMKKEMIS LLSPQKKKPR
ERAEDGTGTA VISDIEDDLG ELSRESAWGL SCDTVREQLT NSIRRQWRIL KSHVEKLDNQ
VSKVHSEGLN DEDVISRQDH EEETEKLELE IQQCKEMIRA QQQLLQQQLA TTCDDDTTSL
LRDCYLLEEK ERLKEEWSLF KEQKKNFERE RRSFTEAAIR LGLERKAFEE ERASWLKQQF
LNMTTFDHQN SENVKLFSAF SGSSDPDNLT VHSRPRQKKP HSVTNGAPAC TSKLAKSLPA
SPSTSDICQT RSCVSEHRSS TNVLNIAPEE TKANEIGREC TNQKWSVMSR PGSREGCYSG
CSSTYTSSHL ERDTLP
//
