ID G3IAT1_CRIGR Unreviewed; 607 AA.
AC G3IAT1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Amiloride-sensitive sodium channel subunit gamma {ECO:0000256|ARBA:ARBA00039160};
DE AltName: Full=Epithelial Na(+) channel subunit gamma {ECO:0000256|ARBA:ARBA00041623};
DE AltName: Full=Gamma-NaCH {ECO:0000256|ARBA:ARBA00042229};
DE AltName: Full=Nonvoltage-gated sodium channel 1 subunit gamma {ECO:0000256|ARBA:ARBA00043111};
DE AltName: Full=SCNEG {ECO:0000256|ARBA:ARBA00041935};
GN ORFNames=I79_020711 {ECO:0000313|EMBL:EGW13021.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13021.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. SCNN1G subfamily. {ECO:0000256|ARBA:ARBA00038067}.
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DR EMBL; JH001751; EGW13021.1; -; Genomic_DNA.
DR AlphaFoldDB; G3IAT1; -.
DR STRING; 10029.G3IAT1; -.
DR PaxDb; 10029-XP_007615851-1; -.
DR eggNOG; KOG4294; Eukaryota.
DR InParanoid; G3IAT1; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF19; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 2.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000313|EMBL:EGW13021.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 54..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 539..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 68916 MW; 899ED52D92C482AF CRC64;
MAPGEKIKAK IKKNLPVRGP QAPTIKDLMH WYCMNTNTHG CRRIVVSRGR LRRLLWILFT
LTAVALIIWQ CALLVFSFYT VSVSIKVHFQ KLDFPAVTIC NINPYKYSAV SDLLTDLDSE
TKQALLSLYG VKDFPEAKAQ KRREARSMRS TGEGSQPRFL NLIPLLLFNE NEKGKATDFF
TGRKRKISGK IIHKASNVMH VHESKKLVGF QLCSNDNSDC ATYTFSSGIN AIQEWYKLHY
MNIMAQVPVD KKINMSYSAE ELLVTCFFDG MSCDARNFTL FHHPMYGNCY TFNNRENATI
LSTSMGGSEY GLQVILYINE DEYNPFLVSS TGAKVLIHQQ NEYPFIEDVG TEIETAMSTS
IGMHLTESFK LSEPYSQCTE DGSDVPITNI YNAAYSLQTK MVEKCGCAQY SQPLPPAANY
CNYQQHPNWM YCYYQLYQAF VREELGCQSV CKQACRTDLA KLLIFYKDLN QRSIMESPAN
SIEMLLSNFG GQLGLWMSCS VVCVIEIIEV FFIDFFSIIA RHQWQKAKDW WARRQAPLSS
ETHSSRQGQD NPALDTDDDL PTFTSAMRLP PAPEATVPGT PPPRYNTLRL DSAFSSQLTD
TQLTNES
//
