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Database: UniProt
Entry: G3ICT9_CRIGR
LinkDB: G3ICT9_CRIGR
Original site: G3ICT9_CRIGR 
ID   G3ICT9_CRIGR            Unreviewed;      1502 AA.
AC   G3ICT9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-DEC-2019, entry version 38.
DE   SubName: Full=Rho GTPase-activating protein 5 {ECO:0000313|EMBL:EGW12688.1};
GN   ORFNames=I79_021490 {ECO:0000313|EMBL:EGW12688.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW12688.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
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DR   EMBL; JH001960; EGW12688.1; -; Genomic_DNA.
DR   STRING; 10029.XP_007618574.1; -.
DR   PRIDE; G3ICT9; -.
DR   InParanoid; G3ICT9; -.
DR   OMA; HIDKVND; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 3.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81698; SSF81698; 1.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT   DOMAIN          266..324
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          365..419
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          426..480
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          481..547
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          589..762
FT                   /note="PG1 pseudoGTPase"
FT                   /evidence="ECO:0000259|PROSITE:PS51852"
FT   DOMAIN          778..943
FT                   /note="PG2 pseudoGTPase"
FT                   /evidence="ECO:0000259|PROSITE:PS51853"
FT   DOMAIN          1262..1449
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          974..1003
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1021..1049
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1070..1089
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1128..1156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1168..1254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          308..328
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1023..1037
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1168..1199
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1231..1248
FT                   /note="Basic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1502 AA;  172317 MW;  2333B4124CF966CA CRC64;
     MAKNKEPRPP SYTVSVVGLS GTEKDKGNCG VGKSCLCNRF VRSKADEYYP EHTSVLSTID
     FGGRVVNNDH FLYWGDITQS GEDGVECKIH VIEQTEFIDD QTFLPHRSTN LQPYIKRAAA
     SKLQSAEKLM YICTDQLGLE QDFEQKQMPE GKLNVDGFLL CIDVSQGCNR KFDDQLKFVN
     NLFVQLSKSK KPVIIAATKC DECVDHYLRE VQAFASNKKN LLVVETSARF NVNIETCFTA
     LVQMLDKTRG KPKIIPYLDA YKTQRQLVVT ATDKFEKLVQ TVRDYHATWK TVSNKLKNHP
     DYEEYINLEG TRKARNTFSK HIEQLKQEHI RKRREEYIST LPRAFNTLLP DLEEIEHLNW
     LEALKLMEKR ADFQLCFVVL EKTPWDETDH IDKINDRRIP FDLLSTLEAE KVYQNHVQHL
     ISEKRRIEMK EKFKKTLEKI QFISPGQPWE EVMCFVMEDE AFKYITEADS KEVYGRHQRE
     IVEKAKEEFQ EMLFEHSELF YDLDLNATPS SDKMSEIHTV LSEEPRYKAL QKLAPDRESL
     LLKHIGFVYH PTKETCLSGQ YCTDIKVEHL LASSLLQLDH GRLRLYHDST NIDKVNLFIL
     GKDGLAQELA NEIRTQSTDD EYALDGKIYE LDLRPVDAKS PYLLSQLWTA AFKPHGCFCV
     FNSIESLSFI GEFIGKIRTE ASQIRKDKYM ANLPFTLILA NQRDSISKNL PILRHQGQQL
     ANKLQCPFVD VPAGTYPRKF NESQIKQALR GVLESVKHNL DVVSPVPINK DVSEADLRIV
     MCAMCGDPFS VDLILSPFLD SHSCSAAQAG QNNSLMLDKI IGEKRRRIQI TILSYHSSIG
     VRKDELVHGY ILVYSAKRKA SMGMLRAFLS EVQDTIPVQL VAVTDSQADF FENEAIKELM
     TEGEHIATEI TAKFTALYSL SQYHRQTEVF TLFFSDVLEK KNMIENSYLS DNTRESTHQS
     EDVFLPSPRD CFPYNNYPDS DDDTEAPPPY SPIGDDVQLL PTPSDRSRYR LDLEGNEYPV
     HSTPNCHDHE RNHKVPPPIK PKPVVPKTNV KKLDPNLLKT IEAGIGKNPR KQISRVPLPH
     PEDVDPSDNY SEPLDTIFKQ KGYPDEIYVV PDDSQNRIIK IRNSFVNNTQ GDEENGFSDR
     TLKGHGERRP SKYKYKSKTL FSKAKSYYRR THSDASDDEA FTTSKTKRKG RHRGSEEDPL
     LSPVETWKGG IDNPAITSDQ EVDDKKMKKK THKVKEDKKQ KKKTKTFNPP TRRNWESNYF
     GMPLQDLVTA EKPIPLFVEK CVEFIEDTGL CTEGLYRVSG NKTDQDNIQK QFDQDHNINL
     VSMEVTVNAV AGALKAFFAD LPDPLIPYSL HPELLEAAKI PDKIERLHAL KEIVKKFHPV
     NYDVFRYVIT HLNRVSQQNK INLMTADNLS ICFWPTLMRP DFENREFLST TKIHQSVVET
     FIQQCQFFFY NGEIVETTNT VPPPPPSNPG QLVESMVPLQ LPPPLQPQLI QPQLQTDPLG
     II
//
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