ID G3ID16_CRIGR Unreviewed; 248 AA.
AC G3ID16;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
GN ORFNames=I79_021577 {ECO:0000313|EMBL:EGW13593.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13593.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- FUNCTION: During development, promotes the survival and differentiation
CC of selected neuronal populations of the peripheral and central nervous
CC systems. Participates in axonal growth, pathfinding and in the
CC modulation of dendritic growth and morphology. Major regulator of
CC synaptic transmission and plasticity at adult synapses in many regions
CC of the CNS. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
CC {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; JH001989; EGW13593.1; -; Genomic_DNA.
DR RefSeq; XP_003512794.1; XM_003512746.3.
DR RefSeq; XP_003512795.1; XM_003512747.3.
DR RefSeq; XP_007625959.1; XM_007627769.2.
DR RefSeq; XP_016825707.1; XM_016970218.1.
DR AlphaFoldDB; G3ID16; -.
DR STRING; 10029.G3ID16; -.
DR PaxDb; 10029-XP_007625956-1; -.
DR GeneID; 100768664; -.
DR CTD; 627; -.
DR eggNOG; ENOG502QRU8; Eukaryota.
DR InParanoid; G3ID16; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF3; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|RuleBase:RU364086}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU364086"
FT CHAIN 19..248
FT /note="Brain-derived neurotrophic factor"
FT /evidence="ECO:0000256|RuleBase:RU364086"
FT /id="PRO_5010897194"
FT DOMAIN 134..241
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 142..209
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 187..238
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 197..240
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
SQ SEQUENCE 248 AA; 27926 MW; EF4151DF15786008 CRC64;
MTILFLTMVI SYFGCMKAAP MKEASIHGQG SLAYPGVRTH GTLESVNGPR AGSRGLSTSL
ADTFEHVIEE LLDEDQKVRP NEENHKDADL YSSRVMLSSQ VPLEPPLLFL LEEYKNYLDA
ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM SGGTVTVLEK VPVSKGQLKQ
YFYETKCNPM GYTKEGCRGI DKRHWNSQCR TTQSYVRALT MDSKKRIGWR FIRIDTSCVC
TLTIKRGR
//
