ID G3IDN0_CRIGR Unreviewed; 1030 AA.
AC G3IDN0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Signal-induced proliferation-associated protein 1 {ECO:0000313|EMBL:EGW13068.1};
GN ORFNames=I79_021813 {ECO:0000313|EMBL:EGW13068.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13068.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
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DR EMBL; JH002077; EGW13068.1; -; Genomic_DNA.
DR AlphaFoldDB; G3IDN0; -.
DR STRING; 10029.G3IDN0; -.
DR PaxDb; 10029-XP_007651510-1; -.
DR eggNOG; KOG3686; Eukaryota.
DR InParanoid; G3IDN0; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF14; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED PROTEIN 1; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 309..527
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 675..751
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 966..1007
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 823..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..965
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 111070 MW; 9BC92B4A478521C0 CRC64;
MAPAPTDDLF ARKLRQPSRP PLTPHTFEPR PARGPLLRSG SDAGEVRPPT PASPCARARA
HSHEDASRPA ATPTRLFTDP LALLGLPAEE PEPTFPPVLE PRWFAHYDVQ SLLFDWAPRP
PGTGSHTEAS SGTQTLAEDQ TATSDLLLGA PGFVCELGGE GELGLGGPVS PPVPPALPNA
AVSVLEEPQT RTTAYSLEHA DLGAGYYRKY FYGKEHQNFF GLDEALGPVA VSLRREEKEG
SGGGTLHSYR VIVRTTQLRT LRGTISEDAL PPGPPRGLSP RKLLEHVAPR LSPTCLRLGS
ASPKVPRTLL TLDEQVLSFQ RKVGILYCRA GQGSEEEMYN NQEAGAAFMQ FLTLLGDVVR
LKGFESYRAQ LDTKTDSTGT HSLYTTYQDH EIMFHVSTML PYTPNNQQQL LRKRHIGNDI
VTIVFQEPGS KPFCPTTIRS HFQHVFLVVR AQAPCTPHTS YRVAVSRTQD TPAFGPALPH
GGGPFAANAD FRAFLLAKAL NGEQAAGHAR QFHAMATRTR QQYLQDLATN EVTTTSLDSA
SRFGLPSLGG RRRATPRGPG AELQAAGALM WGVRAALGAR VAAGAETGGP EGAEVPCLLG
ISAETLVLVA PRDGRVVFNC ACRDVLAWTF SEHQLDLYHG RGEAITLRLD GAPGQAVGEV
VARLQLVSRG CETRELALPR DGQGRLGFEV DAEGFITHVE RFTFAETTGL RPGARLLRVC
GQTLPKLGPE AAAQMLRSAP KVCVTVLPPD ESGRPRRSFS ELYTLSLKEP SRRGAPEPVQ
DGAVKVVLLP PTKQLLHFSL QDNSGPPGPG DLTEERTEFL HSHNSLSTHS SLSDEAPVLP
NTTPDLLLVT TANPSAPGTG RETPPSQDQS GSSSSHEDPS DSAPELRASI LPRTLSLRNS
ISKIMSEAGS ETLEDEWQSI SEIASTCNTI LESLSREGQP VSESGDPKGA PKCDSEPEPG
SLSEKVSHLE SMLKKLQEDL QREKADRAAL EEEVRNLRHN NQRLLAESES AATRLLLASR
QLASPTSDLA
//
