ID G3IDW5_CRIGR Unreviewed; 1028 AA.
AC G3IDW5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=DNA repair protein complementing XP-G cells-like {ECO:0000313|EMBL:EGW00239.1};
GN ORFNames=I79_021903 {ECO:0000313|EMBL:EGW00239.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW00239.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH002108; EGW00239.1; -; Genomic_DNA.
DR AlphaFoldDB; G3IDW5; -.
DR STRING; 10029.G3IDW5; -.
DR PaxDb; 10029-XP_007627078-1; -.
DR eggNOG; KOG2520; Eukaryota.
DR InParanoid; G3IDW5; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd09904; H3TH_XPG; 1.
DR CDD; cd09868; PIN_XPG_RAD2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR001044; XPG/Rad2_eukaryotes.
DR InterPro; IPR019974; XPG_CS.
DR PANTHER; PTHR16171:SF7; DNA EXCISION REPAIR PROTEIN ERCC-5; 1.
DR PANTHER; PTHR16171; DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED; 1.
DR Pfam; PF00867; XPG_I; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR PRINTS; PR00066; XRODRMPGMNTG.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00842; XPG_2; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022759};
KW Nuclease {ECO:0000256|ARBA:ARBA00022759};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 624..693
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 137..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..911
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1028 AA; 114925 MW; 98CAE9812136C995 CRC64;
MDQKQALQEE FFHNPQAIDI ESEDFSSLPP EVKHEILTDM KEFTKRRRTL FEAMPEESND
FSQYQLKGLL KKNYLNQHIE NVQKEMNQQH SGQIQRQYED EGGFLKEVES RRVVSEDTSH
YILIKGIQTK KVMDVDSEAS SSSKMHSMSF GLKSSPHKTV KPEKEPEAAP PSPRTLLAIQ
AAMLGSSSEE EPESGEGRQS RERNLWATAD AGSISPQTLA AIQRALDDDE DGKVCDRGDE
PTGRTLMAVL GDDKDEKVCG RDDELAVRTL LGNVPDQEHS DEVVVRDGGM PFASVPPLPT
MTLVKEGVVS SSSEKEETAS AHSLSTACHQ ASERYAPKEQ MPRIHVVVEA SQISSECEVE
SQQAPLPSAC TELPCSDASR LPSERKLTLV PPTRTHSDQK IDTHSEESGL YPPENKCVSS
CFSSDETESG QNPASKAWST VHVPSEAKGN LEKADEHGDS LRTIQQLEMP EAAARELTLV
PKPMGPMGME SEESESDGSF IDVQSVISDG ELETDSSEAS KPPSEQDEEE PRGTLVEDTP
RDTEHLRQDN FDSEDLANEE HNKADRDAKG SPDEWLDINL EELDSLESNL LAEQNSLEAQ
KQQQERIAAS VTGQMFLESQ ELLRLFGIPY IQAPMEAEAQ CAILDLTDQT SGTITDDSDI
WLFGARHVYK NFFNKNKFVE YYQYVDFHNQ LGLDRNKLIN LAYLLGSDYT EGIPTVGCVT
AMEILNEFPG RGLDPLLKFS EWWHEAQTSK KVAANPHDTK VKKKLRKLQL TPGFPNPAVA
DAYLRPVVDD SRGSFLWGKP DVDKIREFCQ RYFGWNKTKT DESLFPVLKQ LNVQQTQLRI
DSFFKLAQQE KQDAKHIKSQ RLNRAVTCML RKEREEAASE LEKETEALDE AKGKTQKRSL
MSPRETSVPK RRRASGSGGF LGDSHLSESP RDSSEDAESS SVVCTPRGRT AESSTVSCSD
LPDVVRDAHR RDGYMSTSSS GEDDGDKAKA VLVTARPVFG KKKGKLMRRR KRKDQFNKVI
NLEEQCLQ
//
