ID G3IFT6_CRIGR Unreviewed; 235 AA.
AC G3IFT6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Calcium-activated potassium channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE Short=BKbeta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=BK channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Charybdotoxin receptor subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=K(VCA)beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Maxi K channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Slo-beta {ECO:0000256|RuleBase:RU368097};
GN Name=Kcnmb2 {ECO:0000313|Ensembl:ENSCGRP00001006718.1,
GN ECO:0000313|RefSeq:XP_027247621.1};
GN ORFNames=I79_022609 {ECO:0000313|EMBL:EGW07861.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW07861.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW07861.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001006718.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027247621.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027247621.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027247621.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1
CC (maxiK) channel. Modulates the calcium sensitivity and gating kinetics
CC of KCNMA1, thereby contributing to KCNMA1 channel diversity.
CC {ECO:0000256|RuleBase:RU368097}.
CC -!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules
CC of KCMNB per KCNMA1 tetramer. {ECO:0000256|RuleBase:RU368097}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU368097}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU368097}.
CC -!- PTM: N-glycosylated. {ECO:0000256|RuleBase:RU368097}.
CC -!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family.
CC {ECO:0000256|RuleBase:RU368097}.
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DR EMBL; JH002451; EGW07861.1; -; Genomic_DNA.
DR RefSeq; XP_003513652.1; XM_003513604.2.
DR RefSeq; XP_027247621.1; XM_027391820.2.
DR STRING; 10029.G3IFT6; -.
DR PaxDb; 10029-XP_007607097-1; -.
DR Ensembl; ENSCGRT00001010598.1; ENSCGRP00001006718.1; ENSCGRG00001009106.1.
DR GeneID; 100761612; -.
DR KEGG; cge:100761612; -.
DR CTD; 10242; -.
DR eggNOG; ENOG502QSCP; Eukaryota.
DR GeneTree; ENSGT00950000183039; -.
DR OMA; ACYSDPE; -.
DR OrthoDB; 3980853at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 1.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0015269; F:calcium-activated potassium channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005513; P:detection of calcium ion; IEA:UniProtKB-UniRule.
DR GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR Gene3D; 4.10.81.20; KCNMB2, ball/chain domain; 1.
DR InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
DR InterPro; IPR037096; KCNMB2_ball/chain_dom_sf.
DR InterPro; IPR015382; KCNMB2_ball_chain_dom.
DR PANTHER; PTHR10258; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA; 1.
DR PANTHER; PTHR10258:SF5; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-2; 1.
DR Pfam; PF03185; CaKB; 1.
DR Pfam; PF09303; KcnmB2_inactiv; 1.
DR PRINTS; PR01450; BKCHANNELB.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|RuleBase:RU368097};
KW Ion channel {ECO:0000256|RuleBase:RU368097, ECO:0000313|EMBL:EGW07861.1};
KW Ion transport {ECO:0000256|RuleBase:RU368097};
KW Membrane {ECO:0000256|RuleBase:RU368097};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transmembrane {ECO:0000256|RuleBase:RU368097};
KW Transmembrane helix {ECO:0000256|RuleBase:RU368097};
KW Transport {ECO:0000256|RuleBase:RU368097}.
FT TRANSMEM 47..70
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368097"
FT TRANSMEM 200..225
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368097"
FT DOMAIN 1..32
FT /note="KCNMB2 ball/chain"
FT /evidence="ECO:0000259|Pfam:PF09303"
SQ SEQUENCE 235 AA; 27117 MW; 27905615C23B642D CRC64;
MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL GLAMMVCSIM
MYFLLGITLL RSYMQSVWTE EAQCTLLNVS ITETFNCSFS CGPDCWKLSQ YPCLQVYVNL
SSSGEKLLLY HTEETMKINQ KCSYIPKCGN NFEESMSLVS VVMENFRRHQ HFPCYSDPEG
NQKSVILTKL YSSNVLFHSL FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR
//
