ID G3IJV7_CRIGR Unreviewed; 321 AA.
AC G3IJV7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Cytosolic acyl coenzyme A thioester hydrolase {ECO:0000313|EMBL:EGW10852.1, ECO:0000313|RefSeq:XP_027254174.1};
GN Name=Acot7 {ECO:0000313|RefSeq:XP_027254174.1};
GN ORFNames=I79_024146 {ECO:0000313|EMBL:EGW10852.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW10852.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW10852.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_027254174.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027254174.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027254174.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; fatty acid metabolism.
CC {ECO:0000256|ARBA:ARBA00004872}.
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DR EMBL; JH003410; EGW10852.1; -; Genomic_DNA.
DR RefSeq; XP_007631717.1; XM_007633527.2.
DR RefSeq; XP_007653055.1; XM_007654865.2.
DR RefSeq; XP_027254174.1; XM_027398373.2.
DR STRING; 10029.G3IJV7; -.
DR PaxDb; 10029-XP_007631714-1; -.
DR GeneID; 100755154; -.
DR CTD; 11332; -.
DR eggNOG; KOG2763; Eukaryota.
DR InParanoid; G3IJV7; -.
DR OrthoDB; 5393604at2759; -.
DR UniPathway; UPA00199; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP001108280; Chromosome 2.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016790; F:thiolester hydrolase activity; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03442; BFIT_BACH; 2.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR InterPro; IPR040170; Cytosol_ACT.
DR InterPro; IPR033120; HOTDOG_ACOT.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR006683; Thioestr_dom.
DR PANTHER; PTHR11049; ACYL COENZYME A THIOESTER HYDROLASE; 1.
DR PANTHER; PTHR11049:SF34; CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE; 1.
DR Pfam; PF03061; 4HBT; 2.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS51770; HOTDOG_ACOT; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01106,
KW ECO:0000313|EMBL:EGW10852.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487}.
FT DOMAIN 1..109
FT /note="HotDog ACOT-type"
FT /evidence="ECO:0000259|PROSITE:PS51770"
FT DOMAIN 165..279
FT /note="HotDog ACOT-type"
FT /evidence="ECO:0000259|PROSITE:PS51770"
FT REGION 284..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 7
FT /evidence="ECO:0000256|PIRSR:PIRSR640170-1"
FT ACT_SITE 196
FT /evidence="ECO:0000256|PIRSR:PIRSR640170-1"
SQ SEQUENCE 321 AA; 35645 MW; 694530F0845BAFF9 CRC64;
MRPDDANVAG NVHGGTILKM IEEAGAIIST RHCNSQNGER CVAALARVER TDFLSPMCIG
EVAHVSAEIT YTSKHSVEVQ VHVMSENILT GTKKLTNKAT LWYVPLSLKN VDKVLEVPPI
VYSRQELEEE GRKRYEAQKL QRMETTWRNG DMVQPVANPE PNTVSYSQSS LIHLVGPSDC
TLHGFVHGGV TMKLMDEVAG IVAARHCKTN IVTASVDAIN FHDKIRKGCV VTISGRMTFT
SNKSMEIEVL VDADPVVDNS QKRYRAASAF FTYVSLNQEG KPLPVPQLVP ETEDEKKRFE
DGKGRYVQMK AKRQGHTEPQ P
//
