ID G3IKC3_CRIGR Unreviewed; 740 AA.
AC G3IKC3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=glutathione transferase {ECO:0000256|ARBA:ARBA00012452};
DE EC=2.5.1.18 {ECO:0000256|ARBA:ARBA00012452};
GN ORFNames=I79_024324 {ECO:0000313|EMBL:EGV91940.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV91940.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the GST superfamily. Mu family.
CC {ECO:0000256|ARBA:ARBA00005861}.
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DR EMBL; JH003570; EGV91940.1; -; Genomic_DNA.
DR AlphaFoldDB; G3IKC3; -.
DR SMR; G3IKC3; -.
DR STRING; 10029.G3IKC3; -.
DR PaxDb; 10029-XP_007629510-1; -.
DR eggNOG; KOG1695; Eukaryota.
DR InParanoid; G3IKC3; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
DR GO; GO:0042802; F:identical protein binding; IEA:UniProt.
DR CDD; cd03209; GST_C_Mu; 2.
DR CDD; cd03075; GST_N_Mu; 2.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 1.20.1050.130; -; 4.
DR Gene3D; 3.40.30.10; Glutaredoxin; 2.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR003081; GST_mu.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11571; GLUTATHIONE S-TRANSFERASE; 1.
DR PANTHER; PTHR11571:SF219; GLUTATHIONE S-TRANSFERASE MU 3; 1.
DR Pfam; PF00043; GST_C; 3.
DR Pfam; PF14497; GST_C_3; 1.
DR Pfam; PF02798; GST_N; 4.
DR PRINTS; PR01267; GSTRNSFRASEM.
DR SFLD; SFLDG01205; AMPS.1; 1.
DR SFLD; SFLDG00363; AMPS_(cytGST):_Alpha-__Mu-__Pi; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 2.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 4.
DR SUPFAM; SSF52833; Thioredoxin-like; 4.
DR PROSITE; PS50405; GST_CTER; 4.
DR PROSITE; PS50404; GST_NTER; 4.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transferase {ECO:0000313|EMBL:EGV91940.1}.
FT DOMAIN 17..104
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 106..253
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT DOMAIN 185..242
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 244..361
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT DOMAIN 287..372
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 403..460
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT DOMAIN 523..610
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 612..730
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 86560 MW; 0D95E35AAA12451F CRC64;
MREEKRRGEE EREEKQKKKS REKRSRECLT NPIRLLLEYT DSSYEEKKYT MGDAPDFDRS
QWLNEKFKLG LDFPNLPYLI DGSHKITQSN AILRYIARKH NLCGETEEER IRVDIVENQA
MDTRMQLIML CYNPDFEKQK PEFLKTIPEK MKMYSEFLGK RPWFAGDKGL KKISAYMKTS
RFLRRPIFSK MAQWSNKSQW LNEKFKLGLD FPNLPYLIDG SHKITQSNAI LRYIARKHNL
CGETEEERIR VDILENQAMD TRMQLAMVCY SPDFEKRKPE YLEGLPEKMK LYSEFLGKRP
WFAGDKVTYA DFLVYDILDQ HRIFAPKCLD SFPNLKDFLA RFELPYLIDG SHKVTQSNAI
LRYIARKHNL CGETEEERIR VDTLENQVMD TRIQLMIVCC NPDFVTYVDF LAYDILDQYQ
MFEPNCLDAF PNLKDFLARF EGLKKISAYM KTNRFLPSPL CLKQVTWRNN HGELGSMVPG
SAHLGAGQSR SGTAQSPRCA LLLQVESSAR GLTAVSKAGT EIMPVTLGYW DIRGLGHAIR
LLLEYTETSY EEKRYAMGDA PDYDRSQWLN DKFKLGLDFP NLPYLIDGPY KVTQSNAILR
YLGRKHNLCG ETEEERVRVD ILEKQVMDTR IQMGTLCYSP DFEKRKPEFL KGLPDHLKLY
SEFLGTSPWF AGDKITFADF LVYDVLDQHQ MFEPKCLDAF PNLRDFVARF EGLKKISAYM
KTNRFLPSPL YLKQATWGNK
//
