ID G3IKI0_CRIGR Unreviewed; 1020 AA.
AC G3IKI0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 3 {ECO:0000313|EMBL:EGW15086.1};
GN ORFNames=I79_024383 {ECO:0000313|EMBL:EGW15086.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW15086.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBUNIT: The potassium channel is probably composed of a homo- or
CC heterotetrameric complex of pore-forming alpha subunits that can
CC associate with modulating beta subunits.
CC {ECO:0000256|ARBA:ARBA00011552}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JH003624; EGW15086.1; -; Genomic_DNA.
DR AlphaFoldDB; G3IKI0; -.
DR STRING; 10029.G3IKI0; -.
DR eggNOG; KOG0498; Eukaryota.
DR InParanoid; G3IKI0; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR009816; SPATS2-like.
DR PANTHER; PTHR10217:SF481; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 3; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR Pfam; PF07139; SPATS2-like; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01465; ELKCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 456..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 188..236
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 690..754
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 523..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1020 AA; 111031 MW; 5BDFD4FB590034D4 CRC64;
MTCHLLQINA VRAIVPNKSN NEIILVLQHF DNCVDKTVQA FMEGSASDVL KEWIVTGKKK
HFVSERKYDE DLGRVARFTC DVETLKQSID SFGQVSHPKN SYSTRSRCSS VVSVSLSGPG
DVSAASSSPC ASAPSLPGAN KRNCAPGETS AAMTNSSDKP CQAHQERCSL ADSNFVLGNA
QVAGLFPVVY CSDGFCDLTG FSRAEVMQRG CACSFLYGPD TSELVRQQIR KALDEHKEFK
AELILYRKSG GGRRRYGRAG TKGFNANRRR SRAVLYHLSG HLQKQPKGKH KLNKGVFGEK
PNLPEYKVAA IRKSPFILLH CGALRATWDG FILLATLYVA VTVPYSVCVS TAREPSAARG
PPSVCDLAVE VLFILDIVLN FRTTFVSKSG QVVFAPKSIC LHYVTTWFLL DVIAALPFDL
LHAFKVNVYV GAHLLKTVRL LRLLRLLPRL DRYSQYSAVV LTLLMAVFAL LAHWVACIWF
YIGQQEIESK LSCSFSHPSS FPGWLQELAR RLETPYYLVS RTSDGRNSSG QNENCSSRSS
SEANGTGLEL LGGPSLRSAY ITSLYFALSS LTSVGFGNVS ANTDTEKIFS ICTMLIGALM
HAVVFGNVTA IIQRMYARRF LYHSRTRDLR DYIRIHRIPK PLKQRMLEYF QATWAVNNGI
DTTELLQSLP DELRADIAMH LHKEVLQLPL FEAASRGCLR ALSLALRPAF CTPGEYLIHQ
GDALQALYFV CSGSMEVLKG GTVLAILGKG DLIGCELPQR EQVVKANADV KGLTYCVLQC
LQLAGLHESL ALYPEFAPRF SRGLRGELSY NLGAGGVSTE VMELSEQVLQ MREGLQSLRQ
AVQLILVPQG EGQCPRVSGE GPCPATASGL LQPLRVDTGA SSYCLQPPAG SVLSGTWPHP
RPGHPPPLMA PWPWGPPASQ SSPWPRATAL WTSTSDSEPP GSGDLCSEPS TPASPPPSEE
GARTGTPAPV SQAEATSTGE PPPGSGSRAL PWDPHSLEMV LIGCHGPGTV QWTQEEGTGV
//
