ID G3J4G5_CORMM Unreviewed; 930 AA.
AC G3J4G5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=DNA mismatch repair protein MSH2 {ECO:0000313|EMBL:EGX96682.1};
GN ORFNames=CCM_01340 {ECO:0000313|EMBL:EGX96682.1};
OS Cordyceps militaris (strain CM01) (Caterpillar fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=983644 {ECO:0000313|EMBL:EGX96682.1, ECO:0000313|Proteomes:UP000001610};
RN [1] {ECO:0000313|EMBL:EGX96682.1, ECO:0000313|Proteomes:UP000001610}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM01 {ECO:0000313|EMBL:EGX96682.1,
RC ECO:0000313|Proteomes:UP000001610};
RX PubMed=22112802; DOI=10.1186/gb-2011-12-11-r116;
RA Zheng P., Xia Y., Xiao G., Xiong C., Hu X., Zhang S., Zheng H., Huang Y.,
RA Zhou Y., Wang S., Zhao G.P., Liu X., St Leger R.J., Wang C.;
RT "Genome sequence of the insect pathogenic fungus Cordyceps militaris, a
RT valued traditional Chinese medicine.";
RL Genome Biol. 12:RESEARCH116.1-RESEARCH116.21(2011).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; JH126399; EGX96682.1; -; Genomic_DNA.
DR RefSeq; XP_006666559.1; XM_006666496.1.
DR AlphaFoldDB; G3J4G5; -.
DR STRING; 983644.G3J4G5; -.
DR GeneID; 18163371; -.
DR KEGG; cmt:CCM_01340; -.
DR VEuPathDB; FungiDB:CCM_01340; -.
DR eggNOG; KOG0219; Eukaryota.
DR HOGENOM; CLU_002472_10_0_1; -.
DR InParanoid; G3J4G5; -.
DR OMA; LVRFPQK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000001610; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001610}.
FT DOMAIN 736..752
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 930 AA; 103434 MW; AF6FB9729B096FBB CRC64;
MASRPELKKL DDEGSFIRFF KSLPAPNDDT VRIFDRGDWY TSHGDDANYI ANTVYKTTSV
VRQLGRNDHT GLPSVTMTVT VFRQFLREAL FKLGRRVEIW QSPNGRMNWR CAKQASPGNL
QDVEDDLGGQ FESAPMIMSV KISTRASEAR AVGVCFADAS VRELGVSEFL DNDLYSNFEA
LLIQLGVREC LLPQDKSEKD KDPELAKLRQ ILDSCGVAIA ERPAADFGIR DIDQDLARLL
KDETATALLP QTDLKLAMGS AASLIKYLSI LQDPSNFGQY QLYQHDLAQF MKLDAAALKA
LNLMPGPRDG AKTMSIYGVL NHCKTPVGSR LLAQWLKQPL MSKDEIEKRQ QLVEAFVTDT
ELRQTMQETH LRSVPDLYRL SKRFQRNKAD LEDVVRAYQV IIRLPGFLGT LEGVMDEAYR
DPLDAAYTSK LRDLSDSLGR LQDMVEQTVD LDALDRHEYI IKPDYDAGLR IIRKKLDALD
RNIRAEFQEA AADLGQEADK KIFLETSHKV HGVCMRLTRQ EASCIRNRAQ YQECSTQKNG
VYFTTKKLQA YRREHDQLSQ NYNRTQSGLV HEVVQVAASY CPVLERLAGV LAHLDVIVSL
AHCAVHAPEV YVRPTMHPPG GQGQTRLVGA RHPCLELQDD VQFITNDVTL TRDASSFLII
TGPNMGGKST YIRQIGAIAL LAQIGSFVPC TSAELTIFDA VLARVGASDS QLKGVSTFMA
EMLETANILK SATADSLIII DELGRGTSTY DGFGLAWAIS EHIVKEIRCF ALFATHFHEL
TALADQHPNV ANLHVTAHIG GADGGKNGDD GAKREVTLLY KVEPGICDQS FGIHVAELVR
FPDKVVRMAK RKADELEDFT AKHEDLGGLS YSKAHVEEGS ALLKALLVRW RAEVHDAGLS
KEEQVARLKA LVGDDEKLLA NPFFQSVKAL
//
