ID G3JD62_CORMM Unreviewed; 838 AA.
AC G3JD62;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Rho-GTPase-activating protein 8 {ECO:0000313|EMBL:EGX92537.1};
GN ORFNames=CCM_03910 {ECO:0000313|EMBL:EGX92537.1};
OS Cordyceps militaris (strain CM01) (Caterpillar fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=983644 {ECO:0000313|EMBL:EGX92537.1, ECO:0000313|Proteomes:UP000001610};
RN [1] {ECO:0000313|EMBL:EGX92537.1, ECO:0000313|Proteomes:UP000001610}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM01 {ECO:0000313|EMBL:EGX92537.1,
RC ECO:0000313|Proteomes:UP000001610};
RX PubMed=22112802; DOI=10.1186/gb-2011-12-11-r116;
RA Zheng P., Xia Y., Xiao G., Xiong C., Hu X., Zhang S., Zheng H., Huang Y.,
RA Zhou Y., Wang S., Zhao G.P., Liu X., St Leger R.J., Wang C.;
RT "Genome sequence of the insect pathogenic fungus Cordyceps militaris, a
RT valued traditional Chinese medicine.";
RL Genome Biol. 12:RESEARCH116.1-RESEARCH116.21(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH126401; EGX92537.1; -; Genomic_DNA.
DR RefSeq; XP_006669121.1; XM_006669058.1.
DR AlphaFoldDB; G3JD62; -.
DR STRING; 983644.G3JD62; -.
DR GeneID; 18165933; -.
DR KEGG; cmt:CCM_03910; -.
DR VEuPathDB; FungiDB:CCM_03910; -.
DR eggNOG; ENOG502QQWB; Eukaryota.
DR HOGENOM; CLU_008201_1_0_1; -.
DR InParanoid; G3JD62; -.
DR OMA; WSQKQPE; -.
DR OrthoDB; 1328399at2759; -.
DR Proteomes; UP000001610; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04399; RhoGAP_fRGD2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000001610};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..435
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 216..293
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 469..667
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 340..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 93837 MW; EE379A3F44C39AF3 CRC64;
MPGFADSFWS NDYAGGLGVL FGKLQQGVME DRQILTLARL RAEAEDVYGQ RLADIAPAVD
RVSGGFSRDD GATVRKAYDG MRTEMQDAAK SHQRIAQNIR DLVVNPFARW CDAHEARIQD
SQDDLQARTK AHDRQAETVK KLRSNYFNKC RLVEDLEEEN KLAFQEPELS PKNGTQIPEI
KVQPHKEEES REDEEVFEIG DEIYQPDQLR KIISHMLSNI KIGETKVPIL GTYLNTSAGS
DIVEYLQRTM AISSISYAER IGQDLISNGL LRLIGNVGST FANSSKMFYQ WRPKSFRLAG
IPEKKQSLNR TFSLPISESS DSPVVGTVSE YLANWNVLNN SHPNETPTQR LQREGRESDE
KYKSAVKKLD QLRCDLEQAI FLHLKFLEQC ELDRLKAIKT VILDFSGTIS NVIPSLQSTV
DKMMLFQETV QPLGDLRYLL ETYRTGGFVP RVAVYENYYN KVDDQIFGVD LEARARADKK
RVPVVVTAIL TYLDHHYPDL EGDEARRGVW LVDVPLAQTH RLRAKLNNDG AISQEVFSDF
DIPTVASLLK LYLLELPDSL VSTHVYEIVR TIYTTPAAEG TEASRVAVLQ QTLSQLRLSN
IATLDACMNH FTRLIDLTSA DDAYVASLAA TLSRCILRPR AETSLTMEEK HAIRLVRDLF
AHKDAIFSEL KRMSTLSHSS SVGSNNRPRA VSTDESNRKN LVEERNRVIL EKATAIRGRA
TSPAPGTNRH RRDRSTGGPE TRFPIQTSPT TNDRHRSSLG SGLASAVNRL SLEVPADGTM
TPPETLNGAP VGENTRECTD SLTKGTPTRF VGGRRVPNSP PSEEISRGVT LEDKPMDD
//
