ID G3JHF9_CORMM Unreviewed; 403 AA.
AC G3JHF9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Nickel/cobalt efflux system {ECO:0000256|RuleBase:RU362101};
GN ORFNames=CCM_05873 {ECO:0000313|EMBL:EGX91715.1};
OS Cordyceps militaris (strain CM01) (Caterpillar fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=983644 {ECO:0000313|EMBL:EGX91715.1, ECO:0000313|Proteomes:UP000001610};
RN [1] {ECO:0000313|EMBL:EGX91715.1, ECO:0000313|Proteomes:UP000001610}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM01 {ECO:0000313|EMBL:EGX91715.1,
RC ECO:0000313|Proteomes:UP000001610};
RX PubMed=22112802; DOI=10.1186/gb-2011-12-11-r116;
RA Zheng P., Xia Y., Xiao G., Xiong C., Hu X., Zhang S., Zheng H., Huang Y.,
RA Zhou Y., Wang S., Zhao G.P., Liu X., St Leger R.J., Wang C.;
RT "Genome sequence of the insect pathogenic fungus Cordyceps militaris, a
RT valued traditional Chinese medicine.";
RL Genome Biol. 12:RESEARCH116.1-RESEARCH116.21(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362101};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362101}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NiCoT transporter (TC 2.A.52) family.
CC {ECO:0000256|ARBA:ARBA00010892, ECO:0000256|RuleBase:RU362101}.
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DR EMBL; JH126402; EGX91715.1; -; Genomic_DNA.
DR RefSeq; XP_006671080.1; XM_006671017.1.
DR AlphaFoldDB; G3JHF9; -.
DR GeneID; 18167891; -.
DR KEGG; cmt:CCM_05873; -.
DR VEuPathDB; FungiDB:CCM_05873; -.
DR eggNOG; ENOG502RIYK; Eukaryota.
DR HOGENOM; CLU_036094_2_0_1; -.
DR InParanoid; G3JHF9; -.
DR OMA; NGWVLYK; -.
DR OrthoDB; 2725900at2759; -.
DR Proteomes; UP000001610; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015099; F:nickel cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR004688; Ni/Co_transpt.
DR InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR PANTHER; PTHR31611; HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1; 1.
DR PANTHER; PTHR31611:SF0; HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1; 1.
DR Pfam; PF03824; NicO; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362101};
KW Nickel {ECO:0000256|ARBA:ARBA00022596};
KW Reference proteome {ECO:0000313|Proteomes:UP000001610};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362101};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362101};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362101}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 130..151
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 217..241
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 247..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 287..317
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 337..360
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT REGION 381..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 43252 MW; A81E956D973F62FA CRC64;
MALRISLPRK PAFLHGVPNN SLLAIGMLLF ANALVWAACA IILRAHAKLI SPAALAYTLG
LRHALDADHI SAIDLMTRRL IAAGQRPATV GTFFSLGHST VVVVTCVVVA ATSGALRDRF
DGFARVGNIV GTSVSAVFLI VLCVGNGWVL YKLVNRLSEV LAERRRRSDE TGADARVPTE
YDAEATASGQ FNMDGGGLVA RLLGFLFKAI DRPWKMYPLG VVFGLGFDTS SEIAILGIAS
IQAVQGTSIW LILIFPLLFT SGMCLLDTTD GALMMALYTS KAFSRDVVAI LYYSIVLTAI
TVFVAAFIGI IQVLSLVQNV AEPQGRFWDG VSVITDHFEI VGGSIVGVFV VVGLASVLVY
RPWRRRIEGK QQALAASADA GLRDAHEPET PLSQQATPRH LMD
//
