ID G3JHR0_CORMM Unreviewed; 1156 AA.
AC G3JHR0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Telomerase reverse transcriptase {ECO:0000256|ARBA:ARBA00016182, ECO:0000256|RuleBase:RU365061};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493, ECO:0000256|RuleBase:RU365061};
DE AltName: Full=Telomerase catalytic subunit {ECO:0000256|RuleBase:RU365061};
GN ORFNames=CCM_05923 {ECO:0000313|EMBL:EGX91766.1};
OS Cordyceps militaris (strain CM01) (Caterpillar fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=983644 {ECO:0000313|EMBL:EGX91766.1, ECO:0000313|Proteomes:UP000001610};
RN [1] {ECO:0000313|EMBL:EGX91766.1, ECO:0000313|Proteomes:UP000001610}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM01 {ECO:0000313|EMBL:EGX91766.1,
RC ECO:0000313|Proteomes:UP000001610};
RX PubMed=22112802; DOI=10.1186/gb-2011-12-11-r116;
RA Zheng P., Xia Y., Xiao G., Xiong C., Hu X., Zhang S., Zheng H., Huang Y.,
RA Zhou Y., Wang S., Zhao G.P., Liu X., St Leger R.J., Wang C.;
RT "Genome sequence of the insect pathogenic fungus Cordyceps militaris, a
RT valued traditional Chinese medicine.";
RL Genome Biol. 12:RESEARCH116.1-RESEARCH116.21(2011).
CC -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC replication of chromosome termini in most eukaryotes. It elongates
CC telomeres. It is a reverse transcriptase that adds simple sequence
CC repeats to chromosome ends by copying a template sequence within the
CC RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557,
CC ECO:0000256|RuleBase:RU365061};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC subfamily. {ECO:0000256|ARBA:ARBA00008001,
CC ECO:0000256|RuleBase:RU365061}.
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DR EMBL; JH126402; EGX91766.1; -; Genomic_DNA.
DR RefSeq; XP_006671130.1; XM_006671067.1.
DR AlphaFoldDB; G3JHR0; -.
DR STRING; 983644.G3JHR0; -.
DR GeneID; 18167941; -.
DR KEGG; cmt:CCM_05923; -.
DR VEuPathDB; FungiDB:CCM_05923; -.
DR eggNOG; KOG1005; Eukaryota.
DR HOGENOM; CLU_001996_0_1_1; -.
DR InParanoid; G3JHR0; -.
DR OMA; FYVTESN; -.
DR OrthoDB; 55913at2759; -.
DR Proteomes; UP000001610; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IEA:InterPro.
DR CDD; cd01648; TERT; 1.
DR Gene3D; 1.10.132.70; -; 1.
DR Gene3D; 1.10.357.90; -; 1.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR021891; Telomerase_RBD.
DR InterPro; IPR003545; Telomerase_RT.
DR PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF12009; Telomerase_RBD; 1.
DR PRINTS; PR01365; TELOMERASERT.
DR SMART; SM00975; Telomerase_RBD; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU365061};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365061};
KW Reference proteome {ECO:0000313|Proteomes:UP000001610};
KW RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061,
KW ECO:0000313|EMBL:EGX91766.1};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU365061};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
FT DOMAIN 631..994
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1156 AA; 131538 MW; 907D29277C7D33D5 CRC64;
MTKRKRAQKD ASSGKNAKGQ PAPHPLHRDL LNFFYPHCIS LREYALASLP QTSRLRRRKI
KSLGTIPERF ELEKDLCCLL DSTLVCYHQL TPDVADNRWE QWLSFSQRGE DSSVSLTGGS
PIYSQSEIVD FVIWLIFSRD NNGFFGPKHL LCDGYRRRAT EKAEPERIPG VFSRYPNDQV
ASLKAGPWPQ LLNLLGRSGE RIMINMLVDC SIFVAMESGL NNFYQISELE HGLEMKKGPE
KGICARKLSE ISLVRSRVFY ARPPMTSRGH IEAGYRHIRE YQHLGSWSAH QILTTLDALN
RYNYIPEHES TESIVTQKNT LNTAKVMMYV FPRQFGLHNV FTSTVDSKTT VQKLQDYTVR
DDEIAQHMRS DKNFLTQGVP KIPKRLRGAA RDLVRRLQIL HRRCSYIALI RHYCASPLDP
LRERTQKNNE PTSTSKTAPS QAADGKSSKQ ATPSQTQRRT QDSRVFQLDP SVPIVDLATP
VSHVSVFLQA VLSKILPGAF LGEGDDLRHN QALLAKKAHH FVTLRRFESM SLHELSQGFK
ISSLAWLQLP GRGDQKPSQN ETFKQLELFH ELLYYIFDSL LIPLMRNTFY VTESNTHRYQ
VFYFRHDVWK LVSERALRAM KDGMLEELKV GDVQRAVESR RLGFSQIRLL PKGTTLRPIM
NLRRRYPLKQ NKKMLGPSIN TVLAPIHNVL KLEKRLNPSK LGATLFSVGD IYNRLKEFRR
KLPDPLPRLY FVKADVQSAF DTIPQEAVLK LMAAIPSHEH YKIFKHAEVK PGERPPTNTC
TTAPDGASTS HAQAPSRPIR RWHSTAHPGD ESGRFHQRLD GQSSTSGIAA QQPQRKNTVF
VNSAVQSDHD TRGLLRLLAE HVADNRIRVG KKTYRQRRGI PQGSVLSSYL CNYFYADLEA
RHLRFLDDSG SHRSVLLRLV DDFLLVTTDR ARARRFAAVL HRGVPEYGVH VSPHKSLANF
ALSVPPAGGG DDGPPVPIAT VHSTADFPYC GVRISCRTLE IKKDCQREQQ TDVANTLTVE
HSRVPGQNFQ RKVLRDAIPS ISPKKNTTWS PVPSFAYRPG AATDAFKIQS HLMFYDTSHN
SPATVLDTLR AAFRQTALKM WAYMRALHRT ARPRPGLVKL TITRTVEASY LIITSRFRKL
KYQGYECSVR KTQVTR
//
