ID G3JS91_CORMM Unreviewed; 1522 AA.
AC G3JS91;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=ABC drug exporter AtrF {ECO:0000313|EMBL:EGX88790.1};
GN ORFNames=CCM_08836 {ECO:0000313|EMBL:EGX88790.1};
OS Cordyceps militaris (strain CM01) (Caterpillar fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=983644 {ECO:0000313|EMBL:EGX88790.1, ECO:0000313|Proteomes:UP000001610};
RN [1] {ECO:0000313|EMBL:EGX88790.1, ECO:0000313|Proteomes:UP000001610}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM01 {ECO:0000313|EMBL:EGX88790.1,
RC ECO:0000313|Proteomes:UP000001610};
RX PubMed=22112802; DOI=10.1186/gb-2011-12-11-r116;
RA Zheng P., Xia Y., Xiao G., Xiong C., Hu X., Zhang S., Zheng H., Huang Y.,
RA Zhou Y., Wang S., Zhao G.P., Liu X., St Leger R.J., Wang C.;
RT "Genome sequence of the insect pathogenic fungus Cordyceps militaris, a
RT valued traditional Chinese medicine.";
RL Genome Biol. 12:RESEARCH116.1-RESEARCH116.21(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000256|ARBA:ARBA00006012}.
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DR EMBL; JH126405; EGX88790.1; -; Genomic_DNA.
DR RefSeq; XP_006674035.1; XM_006673972.1.
DR GeneID; 18170841; -.
DR KEGG; cmt:CCM_08836; -.
DR VEuPathDB; FungiDB:CCM_08836; -.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_0_1; -.
DR InParanoid; G3JS91; -.
DR OMA; FCISNWA; -.
DR OrthoDB; 5473955at2759; -.
DR Proteomes; UP000001610; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR PANTHER; PTHR19241:SF298; ABC MULTIDRUG TRANSPORTER (EUROFUNG); 1.
DR PANTHER; PTHR19241; ATP-BINDING CASSETTE TRANSPORTER; 1.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001610};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 548..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 800..833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1217..1238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1250..1269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1289..1317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1329..1348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1360..1382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1485..1506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 191..435
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 885..1123
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1522 AA; 168910 MW; 13E22A362C72C560 CRC64;
MAAEEQQTVP TTATAGATDA VTTANPITTT TSADTSSSNA SFEGYWGDAD AGGPVRRESA
RQGYNDLQRE LSRHASNTSG VSKAKSHTAA GRSGGLLSAL RKRPSRAPDV EADSQATKHH
DDDFQLDEFM RQGHLEKRHP ESGESTKKVG VVFKNLTVQG AAMSAMTVRT LPQAILGTFG
PDLYGHLTKL IPALNFGKGS GPEIRDLIHD FTGVVRPGEM MLVLGRPGAG CTTFLKAIAN
NRQGYVAVTG DVRYGGIDAA EMDRRYRGEV VYNPENDRHL PSLTVGQTLE FSLRTKTKKA
DSGRIGLIVD AFLQMFAIAH TKNTNVGDEY TRGVSGGERK RVSIAETLAT KSTVTCWDNS
TRGLDASTAL NYARSLRVMT DVSDRTTLTT LYQAGEGIYE LMDKVLVLDQ GRMLYQGPAT
EARQYFVDLG FFAPPRQTTA DFLTSVCDVN ARRFRDGWAD RCPKTPVELE AAFRASAAYK
SVLADVADYE RHLAATSHVD AETFQQSVQE AKSRTVLQRS NYTVSYWRQV LACTRREFWL
LWGDKQTLYT KFGIIISMGL IVGSLFYDIP SDTSGLFLRG GAAFFSILFL GWLQLSELIR
AIAGRDVIER HKEYAFYRPS AVNFARILAD FPLLFVEVVV FGVILYFMCN FDLDAGKFFI
YLLYIYTTTI CITALYRMFA ALSPSIDDAV RFSGITFNLL LIFTGYAISK PTLISKKIWF
GWFYYINPVS YAFEGVISNE LSSRNMQCAP SQLVPQGPNI LPENQGCAVP GSAAGAATVN
GADYLSANYD YHRSNLWRNW AVLIAFSVLY ILVTVLATET ISFATSGMGI LVFKKSKAGA
AAAKKTKEGD EESGKKEAQG SDNLRRQITT PDEILQEFQR SEKIFTWENV NYTVPSADGP
KKLLNNVQGY AKPGVMVALM GASGAGKTTL LNTLSQRQTV GVVEGSMLVD GTALPTDFQR
GTGFVEQMDL HEESTTVREA LEFSALLRQS KETPRADKIA YVDKIIDLLE MQPLEDAIVF
SLGVEQKKRL TIGVELAAKP SLLLFLDEPT SGLDSQSAFS IIRFLRKLCA AGQAIICTIH
QPSSELIEQF DQILALNPGG NVFYFGPVGE NGSAVVDYFA ARGSQCPDGK NVAEFLIEQG
AKPAGRAFWN EQWLQSDQNK TLTEEIARIK RDRSAAAAQL QHASGGAARQ DEFAASVYEQ
TTLLTKRMFI KQWRQPSYVY GKFFVAVLIG IFNGFTFWQL GNTVEDMQSR MFTSFLVLLF
LPATMNAVLP KFFMDRALWE AREYPSRIYG WVAFCSASIL SEIPSAVISA VLYWILWYYP
TGLPTDSSTA GYVFLMTLLF FLFQTSWAQW ICAFAPSFTV ISNVLPFFLV MFSVFNGVFV
PYEQLAVFWR YWMYYVNPST YFVGGVLSST LAHQQVRCAD SEAAHFTPPS GKTCAEFAGD
FVVKAGRGYL IDPNATDMCG YCPYADGTQY LASLHIEPSQ KWRDFGIFLA FCISNWALVY
FFIYTVRVRR WSFGFNYLFK WF
//
