ID G3JU78_CORMM Unreviewed; 353 AA.
AC G3JU78;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Porphobilinogen deaminase {ECO:0000256|ARBA:ARBA00016519};
DE EC=2.5.1.61 {ECO:0000256|ARBA:ARBA00012655};
DE AltName: Full=Hydroxymethylbilane synthase {ECO:0000256|ARBA:ARBA00033064};
DE AltName: Full=Pre-uroporphyrinogen synthase {ECO:0000256|ARBA:ARBA00030685};
GN ORFNames=CCM_09407 {ECO:0000313|EMBL:EGX87785.1};
OS Cordyceps militaris (strain CM01) (Caterpillar fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=983644 {ECO:0000313|EMBL:EGX87785.1, ECO:0000313|Proteomes:UP000001610};
RN [1] {ECO:0000313|EMBL:EGX87785.1, ECO:0000313|Proteomes:UP000001610}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM01 {ECO:0000313|EMBL:EGX87785.1,
RC ECO:0000313|Proteomes:UP000001610};
RX PubMed=22112802; DOI=10.1186/gb-2011-12-11-r116;
RA Zheng P., Xia Y., Xiao G., Xiong C., Hu X., Zhang S., Zheng H., Huang Y.,
RA Zhou Y., Wang S., Zhao G.P., Liu X., St Leger R.J., Wang C.;
RT "Genome sequence of the insect pathogenic fungus Cordyceps militaris, a
RT valued traditional Chinese medicine.";
RL Genome Biol. 12:RESEARCH116.1-RESEARCH116.21(2011).
CC -!- COFACTOR:
CC Name=dipyrromethane; Xref=ChEBI:CHEBI:60342;
CC Evidence={ECO:0000256|ARBA:ARBA00001916};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
CC {ECO:0000256|ARBA:ARBA00004735}.
CC -!- SIMILARITY: Belongs to the HMBS family.
CC {ECO:0000256|ARBA:ARBA00005638}.
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DR EMBL; JH126407; EGX87785.1; -; Genomic_DNA.
DR RefSeq; XP_006674604.1; XM_006674541.1.
DR AlphaFoldDB; G3JU78; -.
DR STRING; 983644.G3JU78; -.
DR GeneID; 18171410; -.
DR KEGG; cmt:CCM_09407; -.
DR VEuPathDB; FungiDB:CCM_09407; -.
DR eggNOG; KOG2892; Eukaryota.
DR HOGENOM; CLU_019704_0_2_1; -.
DR InParanoid; G3JU78; -.
DR OMA; LWQANHI; -.
DR OrthoDB; 788at2759; -.
DR UniPathway; UPA00251; UER00319.
DR Proteomes; UP000001610; Unassembled WGS sequence.
DR GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR Gene3D; 3.30.160.40; Porphobilinogen deaminase, C-terminal domain; 1.
DR HAMAP; MF_00260; Porphobil_deam; 1.
DR InterPro; IPR000860; HemC.
DR InterPro; IPR022419; Porphobilin_deaminase_cofac_BS.
DR InterPro; IPR022417; Porphobilin_deaminase_N.
DR InterPro; IPR022418; Porphobilinogen_deaminase_C.
DR InterPro; IPR036803; Porphobilinogen_deaminase_C_sf.
DR NCBIfam; TIGR00212; hemC; 1.
DR PANTHER; PTHR11557; PORPHOBILINOGEN DEAMINASE; 1.
DR PANTHER; PTHR11557:SF0; PORPHOBILINOGEN DEAMINASE; 1.
DR Pfam; PF01379; Porphobil_deam; 1.
DR Pfam; PF03900; Porphobil_deamC; 1.
DR PIRSF; PIRSF001438; 4pyrrol_synth_OHMeBilane_synth; 1.
DR PRINTS; PR00151; PORPHBDMNASE.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF54782; Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain; 1.
DR PROSITE; PS00533; PORPHOBILINOGEN_DEAM; 1.
PE 3: Inferred from homology;
KW Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000001610};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 14..230
FT /note="Porphobilinogen deaminase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01379"
FT DOMAIN 244..317
FT /note="Porphobilinogen deaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03900"
SQ SEQUENCE 353 AA; 37348 MW; 9EFC0CB6E352FA4A CRC64;
MSGTQPAADD ATVIRVGTRK SPLALAQAQL VVDALQAALP SHTFPIDSMT TTGDRDQNTA
LYNFGGKGLW TTQLEDKLSR REVDVVVHSL KDMPTELPEG LVLGCITARG DARDTLVVKP
ALAAAHGWAT LADLPAGSVV GTSSIRRIAQ LARRYPQLAF QDHRGNINTR LRKLDEDPRL
AAIILAAAGL QRMAFADRIS QYLDADGAGM LYAVGQGALG IECRAGDVRV LAALEKLKHV
PTTLACLAER SLMRSLEGGC SVPIGVETSW LEDGRLRLRA TVVAVAGDKA VDADEAEVVT
TEEAAEEFGK RIARELVAGG ADEILDAINA SKAAQAKQAE QAAQAVQATQ TAQ
//
